A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
A Comparative Study of Radiological, Functional, and Clinical Outcomes of Three-Pin Versus Five-Pin Techniques for Distal Radius Fracture Fixation. [PDF]
CureusKumar Dake S, Shaik M, Karanam V.
europepmc +1 more source
A generalized version of Holmstedt's formula for the K-functional [PDF]
Irshaad Ahmed +2 more
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Landolt-Börnstein. Numerical data and functional relationships in science and technology. Group III. Crystal and solid state physics. Vol. 7. Crystal structure data of inorganic compounds edited by K.-H. Hellwege and A. M. Hellwege [PDF]
, 1983 J. H. Robertson
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Functional Outcomes After Reoperation for Recurrent Glioma: A Systematic Review and Meta-Analysis of Karnofsky Performance Status with Descriptive Health-Related Quality-of-Life Reporting. [PDF]
Cancers (Basel)Brekke-Kumley B +6 more
europepmc +1 more source
Functional Characterization of a Wheat NHX Antiporter Gene TaNHX2 That Encodes a K+/H+ Exchanger
, 2013 Yuanyuan Xu +7 more
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K-space undersampling strategies for functional and cardiac MRI [PDF]
, 2011 Onur Afacan
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source