Results 131 to 140 of about 2,020,230 (285)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Penerapan Metode K-Means Untuk Clustering Mahasiswa Berdasarkan Nilai Akademik Dengan Weka Interface Studi Kasus Pada Jurusan Teknik Informatika UMM Magelang

open access: yesSemesta Teknika, 2016
The selection process among outstanding students in a department has a big problem. This process is not fair because only involve one criteria and ignore the other criteria.
Asroni Asroni, Ronald Adrian
doaj  

A review of unsupervised k-value selection techniques in clustering algorithms

open access: yesJournal of Industrial Engineering and Management
Purpose: Automatic grouping of data according to certain characteristics is made possible by clustering algorithms, which makes them an essential tool when working with large datasets. However, although they are unsupervised tools, they generally require
Ana Pegado-Bardayo   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Face detection based on K-medoids clustering and associated with convolutional neural networks

open access: yesHeliyon
Over the last several years, the COVID-19 epidemic has spread over the globe. People have become used to the novel standard, which involves working from home, chatting online, and keeping oneself clean, to stop the spread of COVID-19.
Potharla Ramadevi, Raja Das
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

MODIFIKASI K-MEANS BERBASIS ORDERED WEIGHTED AVERAGING (OWA) UNTUK KASUS KLASTERING

open access: yesAgrointek, 2016
K-means clustering method based on Ordered Weighted Averaging (OWA) was developed by Cheng et al (2009) to resolve problem in classification using integrating k-means clustering and OWA.
Millatul Ulya Millatul Ulya
doaj  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Klustering Dengan K-Means Berbasis LVQ Dan K-Means Berbasis OWA

open access: yesJurnal Teknologi Informasi dan Ilmu Komputer, 2015
Dian Eka Ratnawati, Indriati .
doaj   +1 more source

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