Results 131 to 140 of about 2,020,230 (285)
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The selection process among outstanding students in a department has a big problem. This process is not fair because only involve one criteria and ignore the other criteria.
Asroni Asroni, Ronald Adrian
doaj
A review of unsupervised k-value selection techniques in clustering algorithms
Purpose: Automatic grouping of data according to certain characteristics is made possible by clustering algorithms, which makes them an essential tool when working with large datasets. However, although they are unsupervised tools, they generally require
Ana Pegado-Bardayo +3 more
doaj +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Face detection based on K-medoids clustering and associated with convolutional neural networks
Over the last several years, the COVID-19 epidemic has spread over the globe. People have become used to the novel standard, which involves working from home, chatting online, and keeping oneself clean, to stop the spread of COVID-19.
Potharla Ramadevi, Raja Das
doaj +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
MODIFIKASI K-MEANS BERBASIS ORDERED WEIGHTED AVERAGING (OWA) UNTUK KASUS KLASTERING
K-means clustering method based on Ordered Weighted Averaging (OWA) was developed by Cheng et al (2009) to resolve problem in classification using integrating k-means clustering and OWA.
Millatul Ulya Millatul Ulya
doaj
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Klustering Dengan K-Means Berbasis LVQ Dan K-Means Berbasis OWA
Dian Eka Ratnawati, Indriati .
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