Results 121 to 130 of about 11,198,909 (310)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
A novel centroids initialisation for K-means clustering in the presence of benign outliers [PDF]
K-means is one of the most important and widely applied clustering algorithms in learning systems. However, it suffers from centroids initialisation that makes K-means algorithm unstable.
Ghazanfar, Mustansar Ali +2 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Intrusion detection system using hybird gsa-k-means [PDF]
, 2013 Security is an important aspect in our daily life. Intrusion Detection Systems (IDS) are developed to be the defense against security threats. Current signature based IDS like firewalls and antiviruses, which rely on labeled training data, generally ...
Aslahi Shahri, Bibi Masoomeh
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
An optimized initialization center K-means clustering algorithm based on density
, 2015 Traditional K-means algorithm's clustering effect is affected by the initial cluster center points. To solve this problem, a method is proposed to optimize the K-means initial center points.
Xiaofeng Zhou +5 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
ANALISIS K-MEANS CLUSTER INDEKS PEMBANGUNAN MANUSIA DI INDONESIA
, 2019 Pembangunan manusia dalam suatu negara diperlukan untuk menciptakan kesejahteraan dan membuat perkembangan dalam suatu negara sehingga perlu dilihat terlebih dahulu kualitas sumber daya manusia dalam negara tersebut.
ANALISIS K-MEANS CLUSTER INDEKS PEMBANGUNAN MANUSIA DI INDONESIA, 4112315018
core
Combining the Kohonen Self-Organizing Map and K-Means for On-Line Classification of Sensordata [PDF]
, 2001 Many devices, like mobile phones, use contextual profiles like in the car or in a meeting to quickly switch between behaviors. Achieving automatic context detection, usually by analysis of small hardware sensors, is a fundamental problem in human ...
Van Laerhoven, Kristof
core