Results 81 to 90 of about 938,196 (259)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Initializing k-means Clustering

Proceedings of the 9th International Conference on Data Science, Technology and Applications, 2020
The quality of clustering results obtained with the k-means algorithm depends heavily on the initialization of the cluster centers. Simply sampling centers uniformly at random from the data points usually yields fairly poor and unstable results. Hence several alternatives have been suggested in the past, among which Maximin (Hathaway et al., 2006) and ...
Borgelt, Christian, Yarikova, Olha
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Centroid Update Approach to K-Means Clustering

Advances in Electrical and Computer Engineering, 2017
The volume and complexity of the data that is generated every day increased in the last years in an exponential manner. For processing the generated data in a quicker way the hardware capabilities evolved and new versions of algorithms were created ...
BORLEA, I.-D., PRECUP, R.-E., DRAGAN, F., BORLEA, A.-B.   +3 more
doaj   +1 more source

Approximation Algorithms for Bregman Co-clustering and Tensor Clustering

, 2008
In the past few years powerful generalizations to the Euclidean k-means problem have been made, such as Bregman clustering [7], co-clustering (i.e., simultaneous clustering of rows and columns of an input matrix) [9,18], and tensor clustering [8,34 ...
Banerjee, Arindam, Jegelka, Stefanie, Sra, Suvrit   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Segmentasi Pelanggan menggunakan Metode K-means Clustering Berdasarkan Model RFM pada Bisnis Food and Beverage (Studi Kasus: Coffee shop X)

Jurnal Teknologi dan Sistem Informasi
Data tidak bisa dipisahkan dari bidang industri yang semakin maju. Analisis ini menyoroti kekuatan big data dalam industri food and beverages. Dengan menggunakan profil pelanggan dan analisis transaksi, bisnis dapat memperoleh wawasan pelanggan yang ...
Anggita Nurlathifa, Diarany Sucahyati
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source