Results 51 to 60 of about 131,772 (305)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Nearest-Neighbor-Based Active Learning for Rare Category Detection
, 2018 Rare category detection is an open challenge for active learning, especially in the de-novo case (no labeled examples), but of significant practical importance for data mining - e.g.
Jaime G. Carbonell (5361842) +1 more
core +2 more sources
Asymptotics of k-nearest Neighbor Riesz Energies
Constructive Approximation, 2023 We obtain new asymptotic results about systems of $ N $ particles governed by Riesz interactions involving $ k $-nearest neighbors of each particle as $N\to\infty$. These results include a generalization to weighted Riesz potentials with external field.
Hardin, Douglas P. +2 more
openaire +3 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A Continuous k-Nearest Neighbor Query Method for Moving Data in Obstructed Spaces
Journal of Harbin University of Science and Technology, 2018 For the nearest neighbor query problem of continuous moving objects in spatio-temporal databases, the COpKNN (continuous obstructed possible k-nearest neighbor) query is proposed: in a two-dimensional space, given a moving query point q, a set of moving ...
WAN Jing +3 more
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Fast Approximate Complete-data k-nearest-neighbor Estimation
Austrian Journal of Statistics, 2020 We introduce a fast method to estimate the complete-data set of k-nearest-neighbors.This is equivalent to finding an estimate of the k-nearest-neighbor graph of the data. The method relies on random normal projections.
Alejandro Murua, Nicolas Wicker
doaj +1 more source
Pilar Nusa Mandiri, 2022 Classification of blood donor data at UTD PMI Bali Province by applying the C4.5 and K-Nearest Neighbor algorithms. The number of blood donor data donors is 34,948, of which 90% of the data, namely 31,454 is used as training data.
Ni Ketut Melly Astuti +2 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
JOIV: International Journal on Informatics VisualizationHaving a healthy baby is a dream for mothers. Unfortunately, high maternal and fetal mortality has become a vital problem that requires early risk detection for pregnant women.
Muchamad Kurniawan +4 more
doaj +1 more source