Results 61 to 70 of about 88,733 (260)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Kinetic Reverse k-Nearest Neighbor Problem [PDF]

, 2015
This paper provides the first solution to the kinetic reverse $k$-nearest neighbor (\rknn) problem in $\mathbb{R}^d$, which is defined as follows: Given a set $P$ of $n$ moving points in arbitrary but fixed dimension $d$, an integer $k$, and a query point $q\notin P$ at any time $t$, report all the points $p\in P$ for which $q$ is one of the $k ...
Zahed Rahmati, Valerie King, Sue Whitesides   +2 more
openaire   +4 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

PARAMETER INDEPENDENT FUZZY WEIGHTED k-NEAREST NEIGHBOR

Media Statistika
Parameter Independent Fuzzy Weighted k-Nearest Neighbor (PIFWkNN) as a classification technique developed by combining Success History based Parameter Adaptive Differential Evolution (SHADE) with Fuzzy k-Nearest Neighbor (FkNN), where this PIFWkNN does ...
Mayawi Mayawi, Subanar Subanar
doaj   +1 more source

Using K-Nearest Neighbor in Optical Character Recognition

ComTech, 2016
The growth in computer vision technology has aided society with various kinds of tasks. One of these tasks is the ability of recognizing text contained in an image, or usually referred to as Optical Character Recognition (OCR).
Veronica Ong, Derwin Suhartono
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

k-Nearest Neighbor Curves in Imaging Data Classification

Frontiers in Applied Mathematics and Statistics, 2019
Background: Lung disease quantification via medical image analysis is classically difficult. We propose a method based on normalized nearest neighborhood distance classifications for comparing individual CT scan air-trapping distributions (representing ...
Yann Cabon, Yann Cabon, Carey Suehs, Carey Suehs, Sébastien Bommart, Sébastien Bommart, Isabelle Vachier, Isabelle Vachier, Gregory Marin, Arnaud Bourdin, Arnaud Bourdin, Nicolas Molinari, Nicolas Molinari   +12 more
doaj   +1 more source