Results 121 to 130 of about 652,491 (276)
Dilated-RNNs: A Deep Approach for Continuous Volcano-Seismic Events Recognition
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingMonitoring continuous volcano-seismic signals is often performed by systems trained on scarce or incomplete datasets. From a machine learning perspective, these types of systems are typically built by learning from seismic records containing information ...
Manuel Titos +4 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Speech and ethical training of future specialists in preschool education: conceptual glossary
Науковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. УшинськогоThe article positions the implementation of strategic goals for the development of preschool education, as defined in the content of the new strategic document "A Vision of the Future of Education and Science of Ukraine" (MES of Ukraine, 2023), which ...
Bogush Alla
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Discrete Dynamics in Nature and Society, 2004 The existence of positive periodic solutions for a delayed discrete predator-prey model with Holling-type-III functional response N1(k+1)=N1(k)exp{b1(k)−a1(k)N1(k−[τ1])−α1(k)N1(k)N2(k)/(N12(k)+m2N22(k))}, N2(k+1)=N2(k)exp{−b2(k)+α2(k)N12(k−[τ2])/(N12(k ...
Lin-Lin Wang, Wan-Tong Li
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Homology stability for orthogonal groups over algebraically closed fields [PDF]
, 2007 Cathelineau, Jean-Louis
core +1 more source