Results 1 to 10 of about 135,060 (164)

Highly selective photoaffinity labeling of mu and delta opioid receptors. [PDF]

Proc Natl Acad Sci U S A, 1984
Garbay-Jaureguiberry C, Robichon A, Daugé V, Rossignol P, Roques BP.   +4 more
europepmc   +1 more source

Evolutionary and functional history of the Escherichia coli K1 capsule

Nature Communications, 2023
Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in E.
S. Arredondo-Alonso, George Blundell-Hunter, Zuyi Fu, R. Gladstone, Alfred Fillol-Salom, Jessica Loraine, E. Cloutman-Green, P. Johnsen, Ørjan Samuelsen, A. K. Pöntinen, François Cléon, S. Chavez-Bueno, Miguel A. De la Cruz, Miguel A. Ares, M. Vongsouvath, A. Chmielarczyk, C. Horner, N. Klein, A. McNally, J. Reis, José R. Penadés, N. Thomson, J. Corander, P. Taylor, A. McCarthy   +24 more
semanticscholar   +1 more source

TSH receptor specific monoclonal autoantibody K1‐70TM targeting of the TSH receptor in subjects with Graves' disease and Graves' orbitopathy—Results from a phase I clinical trial

Clinical Endocrinology, 2022
In Graves' disease (GD), autoantibodies to the thyroid stimulating hormone receptor (TSHR) cause hyperthyroidism. The condition is often associated with eye signs including proptosis, oedema, and diplopia (collectively termed Graves' orbitopathy [GO ...
J. Furmaniak, J. Sanders, P. Sanders, Yang Li, Bernard Rees Smith   +4 more
semanticscholar   +1 more source

Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injury

Cellular and Molecular Life Sciences, 2022
Ferroptosis, a type of iron-dependent programmed cell death distinct from apoptosis, necroptosis, and other types of cell death, is characterized by lipid peroxidation, reactive oxygen species production, and mitochondrial dysfunction.
Benedikt Kolbrink, F. V. von Samson-Himmelstjerna, M. L. Messtorff, Theresa Riebeling, Raphael Nische, J. Schmitz, J. Bräsen, U. Kunzendorf, S. Krautwald   +8 more
semanticscholar   +1 more source

Vitamin K1 and progression of cardiovascular calcifications in hemodialysis patients: the VitaVasK randomized controlled trial

Clinical Kidney Journal, 2022
Background Cardiovascular calcifications are prevented by matrix Gla protein (MGP), a vitamin K–dependent protein. Haemodialysis patients exhibit marked vitamin K deficiency.
Turgay Saritas, S. Reinartz, Thilo Krüger, M. Ketteler, O. Liangos, L. Labriola, P. Stenvinkel, C. Kopp, R. Westenfeld, P. Evenepoel, R. Siepmann, S. Wied, R. Hilgers, L. Schurgers, J. Floege   +14 more
semanticscholar   +1 more source

Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use

Journal of Biomedical Sciences, 2022
K1 capsular polysaccharide (CPS)-associated Klebsiella pneumoniae is the primary cause of pyogenic liver abscesses (PLA) in Asia. Patients with PLA often have serious complications, ultimately leading to a mortality of ~ 5%. This K1 CPS has been reported
I. Tu, Tzu‐Lung Lin, Feng‐Ling Yang, I-Ming Lee, Weihong Tu, J. Liao, T. Ko, Wen-Jin Wu, J. Jan, M. Ho, Ching-Yi Chou, A. H. Wang, Chung-Yi Wu, Jin-Town Wang, Kai-Fa Huang, Shih-Hsiung Wu   +15 more
semanticscholar   +1 more source

Emergence of K1 ST23 and K2 ST65 hypervirulent klebsiella pneumoniae as true pathogens with specific virulence genes in cryptogenic pyogenic liver abscesses Shiraz Iran

Frontiers in Cellular and Infection Microbiology, 2022
Hypervirulent Klebsiella pneumoniae (hvKp) pathotype is emerging worldwide in pyogenic liver abscesses (PLAs). However, the role of virulence factors in pathogenicity remains unclear. On the other hand, the epidemiology of PLAs in Iran is unknown.
M. Sohrabi, Mahvash Alizade Naini, A. Rasekhi, M. Oloomi, F. Moradhaseli, Abbas Ayoub, A. Bazargani, Z. Hashemizadeh, F. Shahcheraghi, F. Badmasti   +9 more
semanticscholar   +1 more source

The Long and Winding Road towards FAIR Data as an Integral Component of the Computational Modelling and Dissemination of Chemistry

Israel Journal of Chemistry, Volume 62, Issue 1-2, February 2022., 2022
Abstract Fifty years of the author‘s activities as a “computational chemist” are described, linked by the theme of scientific data. For the first half of this period, data was often handled in a very impoverished way, appearing as in printed form as supporting information or as appendices in e. g.
Henry S. Rzepa
wiley   +1 more source

Novel Host Recognition Mechanism of the K1 Capsule-Specific Phage of Escherichia coli: Capsular Polysaccharide as the First Receptor and Lipopolysaccharide as the Secondary Receptor

Journal of Virology, 2021
It has been speculated that CPS is the main receptor of K1-specific phages belonging to Siphoviridae. In recent years, a new type of K1-specific phage belonging to Myoviridae has been reported, but its host recognition mechanisms remain unknown. ABSTRACT
Qianwen Gong, Xuhang Wang, Haosheng Huang, Yu Sun, Xinjie Qian, Feng Xue, Jianluan Ren, Jianjun Dai, F. Tang   +8 more
semanticscholar   +1 more source