Results 71 to 80 of about 2,095 (193)

UFMylation System: Biological Functions, Molecular Mechanisms, Diseases, and Drug Discovery

MedComm, Volume 6, Issue 10, October 2025.
UFMylation, a novel ubiquitin‐like modification, plays an essential role in various cellular processes, such as the immune response, DNA damage repair, unfolded protein response (UPR), autophagy, endoplasmic reticulum (ER)‐phagy, stem cell self‐renewal, apoptosis, and metastasis.
Huiyan Li, Fei Meng, Junjie Liang, Yijie Wang, Changliang Shan, Yan Chen   +5 more
wiley   +1 more source

Inter-scallop separations of the posterior leaflet of the mitral valve: an important cause of ‘pathological’ mitral regurgitation in rheumatic heart disease screening

Echo Research and Practice, 2018
The 2012 World Heart Federation (WHF) criteria for echocardiographic diagnosis of rheumatic heart disease (RHD) identify that the finding of ‘pathological’ mitral regurgitation (MR) in a screened individual increases the likelihood of detecting ...
L D Hunter, M Monaghan, G Lloyd , A J K Pecoraro, A F Doubell, P G Herbst   +5 more
doaj   +1 more source

Genetic code expansion and enzymatic modifications as accessible methods for studying site‐specific post‐translational modifications of alpha‐synuclein and tau

Protein Science, Volume 34, Issue 10, October 2025.
Abstract Alpha‐synuclein (αS) and tau play important roles in the pathology of Parkinson's disease and Alzheimer's disease, respectively, as well as numerous other neurodegenerative diseases. Both proteins are classified as intrinsically disordered proteins (IDPs), as they have no stable structure that underlies their function in healthy tissue, and ...
Ibrahim G. Saleh, Marie Shimogawa, Jennifer Ramirez, Bernard Abakah, Yarra Venkatesh, Honey Priya James, Ming‐Hao Li, Sarah A. Louie, Marshall G. Lougee, Wai‐Kit Chia, Christopher Brue, Richard B. Cooley, Ryan A. Mehl, Tobias Baumgart, Robert H. Mach, David Eliezer, Elizabeth Rhoades, E. James Petersson   +17 more
wiley   +1 more source

Mutu Sap Liquid Rumput Laut Sargassum yang Diekstrak Menggunakan Kalium Hidroksida sebagai Bahan Pupuk

Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan, 2015
Penelitian ekstraksi sap dari rumput laut Sargassum telah dilakukan dengan menggunakan larutan KOH. Sebelum dilakukan perlakuan Sargassum direndam dalam HCl 1% selama 2 jam, dicuci dengan air tawar dan ditiriskan.
Jamal Basmal, Rinta Kusumawati, Bagus Sediadi Bandol Utomo   +2 more
doaj   +1 more source

Crystal structure and biophysical characterisation of the enterococcal foldase PpiC, a cross‐opsonic antigen against gram‐positive nosocomial pathogens

The FEBS Journal, Volume 292, Issue 20, Page 5475-5490, October 2025.
PpiC is an enterococcal lipoprotein endowed with both Peptidyl‐prolyl cis‐trans isomerase (PPIase) and foldase activities. It is a potential target for novel antimicrobials and a promising vaccine antigen. We determined the crystal structure of the enzyme, showing that PpiC adopts a dimeric organisation embedding two catalytic parvulin‐type PPIase ...
Valeria Napolitano, Eliza Kramarska, Ornella Ghilardi, Felipe Romero‐Saavedra, Pompea Del Vecchio, Flavia Squeglia, Johannes Huebner, Rita Berisio   +7 more
wiley   +1 more source

Effect of a ceruminolytic ear cleaner on clinical, microbiological and ear canal microbiome evolution in canine erythemato‐ceruminous otitis externa associated with proliferation of Malassezia yeasts

Veterinary Dermatology, Volume 36, Issue 5, Page 668-678, October 2025.
Background – Erythemato‐ceruminous otitis externa (ECOE) is commonly associated with Malassezia spp. and microbial imbalance. Hypothesis/Objective – To assess the clinical performance of an ear cleaner in dogs suffering from ECOE associated with Malassezia spp. overgrowth and to measure its impact on the microbiota. Conclusions and Clinical Relevance –
Amaury Briand, Emmanuel Bensignor, Hélène Dropsy, Odile Crosaz, Louis Humeau, Justine Cheval, Vanessa Demontant, Melissa N. Debi, Oscar Fantini, Hélène Dal, Jacques Guillot, Noelle Cochet Faivre   +11 more
wiley   +1 more source

Protective Effects of Oridonin on Acute Liver Injury via Impeding Posttranslational Modifications of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) in the Toll-Like Receptor 4 (TLR4) Signaling Pathway

Mediators of Inflammation, 2019
Objective. Recent researches have demonstrated that inflammation-related diseases are effectively regulated by posttranslational modifications (PTMs) including phosphorylation and acetylation.
Min Shi, Yilin Deng, Heguo Yu, Ling Xu, Cuicui Shi, Jiong Chen, Guangming Li, Yiqi Du, Yu-gang Wang   +8 more
doaj   +1 more source

Mutu Sap Liquid Rumput Laut Sargassum yang Diekstrak Menggunakan Kalium Hidroksida sebagai Bahan Pupuk

Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan, 2016
Penelitian ekstraksi sap dari rumput laut Sargassum telah dilakukan dengan menggunakan larutan KOH. Sebelum dilakukan perlakuan Sargassum direndam dalam HCl 1% selama 2 jam, dicuci dengan air tawar dan ditiriskan.
Jamal Basmal, Rinta Kusumawati, Bagus Sediadi Bandol Utomo   +2 more
doaj   +1 more source

On Combining Conventional Point‐To‐Point and Automated Waste Collection Systems

Networks, Volume 86, Issue 2, Page 174-198, September 2025.
ABSTRACT The global demand for sustainable waste management has spurred initiatives to improve the efficiency of urban waste collection, discussing the advantages and disadvantages of different systems. We analyze a new combined waste collection problem that uses two systems simultaneously: a point‐to‐point system, in which waste is collected using ...
Maryam DehghanChenary, Richard F. Hartl, Stefan Irnich, Christian Tilk   +3 more
wiley   +1 more source

Modeling radiative transfer in tropical rainforest canopies: sensitivity of simulated albedo to canopy architectural and optical parameters

Anais da Academia Brasileira de Ciências, 2011
This study evaluates the sensitivity of the surface albedo simulated by the Integrated Biosphere Simulator (IBIS) to a set of Amazonian tropical rainforest canopy architectural and optical parameters.
Sílvia N. M. Yanagi, Marcos H. Costa
doaj   +1 more source