Homooligomeric and Heterooligomeric Associations between K+-Cl– Cotransporter Isoforms and between K+-Cl– and Na+-K+-Cl– Cotransporters* [PDF]
Journal of Biological Chemistry, 2007 Little is known regarding the quaternary structure of cation-Cl– cotransporters (CCCs) except that the Na+-dependent CCCs can exist as homooligomeric units.
Charles F. Simard +6 more
semanticscholar +5 more sources
Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation. [PDF]
J Biol Chem, 2009 The neuronal K+-Cl− cotransporter (KCC2) is a membrane transport protein that extrudes Cl− from neurons and helps maintain low intracellular [Cl−] and hyperpolarizing GABAergic synaptic potentials.
Watanabe M +3 more
europepmc +4 more sources
K-Cl cotransporters, cell volume homeostasis, and neurological disease. [PDF]
Trends Mol Med, 2015 K(+)-Cl(-) cotransporters (KCCs) were originally characterized as regulators of red blood cell (RBC) volume. Since then, four distinct KCCs have been cloned, and their importance for volume regulation has been demonstrated in other cell types. Genetic models of certain KCCs, such as KCC3, and their inhibitory WNK-STE20/SPS1-related proline/alanine-rich
Kahle KT +6 more
europepmc +6 more sources
Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. [PDF]
Biochim Biophys Acta, 2010 Precise regulation of the intracellular concentration of chloride [Cl-]i is necessary for proper cell volume regulation, transepithelial transport, and GABA neurotransmission. The Na-K-2Cl (NKCCs) and K-Cl (KCCs) cotransporters, related SLC12A transporters mediating cellular chloride influx and efflux, respectively, are key determinants of [Cl-]i in ...
Kahle KT, Rinehart J, Lifton RP.
europepmc +5 more sources
Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.
Am J Physiol Renal Physiol, 2013 K(+)-Cl(-) cotransporter (KCC) isoforms 3 (KCC3) and 4 (KCC4) are expressed at the basolateral membrane of proximal convoluted tubule cells, and KCC4 is present in the basolateral membrane of the thick ascending loop of Henle's limb and α-intercalated ...
Melo Z +8 more
europepmc +4 more sources
Functional Comparison of the K+-Cl−Cotransporters KCC1 and KCC4* [PDF]
Journal of Biological Chemistry, 2000 The K+-Cl−cotransporters (KCCs) are members of the cation-chloride cotransporter gene family and fall into two phylogenetic subgroups: KCC2 paired with KCC4 and KCC1 paired with KCC3.
A. Mercado +4 more
semanticscholar +6 more sources
With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.
Am J Physiol Cell Physiol, 2016 The K(+)-Cl(-) cotransporters (KCC1-KCC4) encompass a branch of the SLC12 family of electroneutral cation-coupled chloride cotransporters that translocate ions out of the cell to regulate various factors, including cell volume and intracellular chloride ...
Mercado A +9 more
europepmc +2 more sources
Am J Physiol Renal Physiol, 2017 Calcineurin dephosphorylates nuclear factor of activated T cells transcription factors, thereby facilitating T cell-mediated immune responses. Calcineurin inhibitors are instrumental for immunosuppression after organ transplantation but may cause side ...
Blankenstein KI +9 more
europepmc +2 more sources
Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4. [PDF]
J Biol Chem, 2010 K+Cl− cotransporters (KCCs) play fundamental physiological roles in processes such as inhibitory neurotransmission and cell volume regulation. Mammalian genomes encode four distinct KCC paralogs, which share basic transport characteristics but differ ...
Hartmann AM +6 more
europepmc +2 more sources
A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters. [PDF]
J Biol Chem, 2014 Background: WNK4 acts upstream of SPAK/OSR1 in the regulation of Na-K-2Cl cotransporters. Results: Here we show that WNK4 directly binds to NKCC1, and in the presence of Cab39 it stimulates NKCC1 activity.
Ponce-Coria J +6 more
europepmc +2 more sources