Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs [PDF]
eLife, 2020 Cation-chloride-cotransporters (CCCs) catalyze transport of Cl- with K+ and/or Na+across cellular membranes. CCCs play roles in cellular volume regulation, neural development and function, audition, regulation of blood pressure, and renal function.
Michelle S Reid +2 more
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K-Cl cotransporters, cell volume homeostasis, and neurological disease. [PDF]
Trends Mol Med, 2015 K(+)-Cl(-) cotransporters (KCCs) were originally characterized as regulators of red blood cell (RBC) volume. Since then, four distinct KCCs have been cloned, and their importance for volume regulation has been demonstrated in other cell types. Genetic models of certain KCCs, such as KCC3, and their inhibitory WNK-STE20/SPS1-related proline/alanine-rich
Kahle KT +6 more
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The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies [PDF]
Journal of Pharmaceutical Analysis, 2023 The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises potassium chloride cotransporters (KCCs, e.g. KCC1, KCC2, KCC3, and KCC4)-mediated Cl− extrusion, and sodium potassium chloride cotransporters (N[K]CCs, NKCC1, NKCC2,
Shiyao Zhang +15 more
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Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters [PDF]
FEBS Open BioThe cation‐chloride cotransporter (CCC) family includes ion symporters that cotransport monovalent cations and Cl−, playing a crucial role in controlling cytoplasmic ion content.
Satoshi Fudo +4 more
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Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity [PDF]
Cell, 2009 Modulation of intracellular chloride concentration ([Cl(-)](i)) plays a fundamental role in cell volume regulation and neuronal response to GABA. Cl(-) exit via K-Cl cotransporters (KCCs) is a major determinant of [Cl(-)](I); however, mechanisms governing KCC activities are poorly understood.
Jesse Rinehart +14 more
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Sevoflurane-induced regulation of NKCC1/KCC2 phosphorylation through activation of Spak/OSR1 kinase and cognitive impairment in ischemia-reperfusion injury in rats [PDF]
HeliyonThe occurrence of excitotoxic damage caused by cerebral ischemia-reperfusion (I/R) injury is closely linked to a decrease in central inhibitory function, in which the concentration of chloride inside the cells ([Cl−]i) plays a crucial role.
Yuefeng Wang +5 more
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Bio-Protocol, 2021 Cation-chloride cotransporters (CCCs) mediate the coupled, electroneutral symport of cations such as Na+ and/or K+ with chloride across membrane.
Si Liu, Jiangtao Guo
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A trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport function. [PDF]
PLoS ONE, 2013 The K-Cl cotransporter (KCC) functions in maintaining chloride and volume homeostasis in a variety of cells. In the process of cloning the mouse KCC3 cDNA, we came across a cloning mutation (E289G) that rendered the cotransporter inactive in functional ...
Jinlong Ding +2 more
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Nature Communications, 2022 Loop diuretics including bumetanide inhibit Na+-K+-Cl−-cotransporters (NKCCs) and are used for the treatment of edema and hypertension. Here, Zhao et. al.
Yongxiang Zhao +6 more
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Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia. [PDF]
PLoS ONE, 2015 Alterations in GABAergic neurotransmission are implicated in several psychiatric illnesses, including schizophrenia. The Na-K-Cl and K-Cl cotransporters regulate intracellular chloride levels.
Courtney R Sullivan +4 more
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