Results 41 to 50 of about 3,400 (190)
Functional Comparison of the K+-Cl−Cotransporters KCC1 and KCC4 [PDF]
Journal of Biological Chemistry, 2000 The K(+)-Cl(-) cotransporters (KCCs) are members of the cation-chloride cotransporter gene family and fall into two phylogenetic subgroups: KCC2 paired with KCC4 and KCC1 paired with KCC3. We report a functional comparison in Xenopus oocytes of KCC1 and KCC4, widely expressed representatives of these two subgroups.
A, Mercado +4 more
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Coordinate modulation of Na-K-2Cl cotransport and K-Cl cotransport by cell volume and chloride [PDF]
American Journal of Physiology-Cell Physiology, 2002 Na-K-2Cl cotransporter (NKCC) and K-Cl cotransporter (KCC) play key roles in cell volume regulation and epithelial Cl− transport. Reductions in either cell volume or cytosolic Cl− concentration ([Cl−]i) stimulate a corrective uptake of KCl and water via NKCC, whereas cell swelling triggers KCl loss via KCC.
Christian, Lytle, Thomas, McManus
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Computation of Pump-Leak Flux Balance in Animal Cells
Cellular Physiology and Biochemistry, 2014 Background/Aims: Many vital processes in animal cells depend on monovalent ion transport across the plasma membrane via specific pathways. Their operation is described by a set of nonlinear and transcendental equations that cannot be solved analytically.
Igor A. Vereninov +4 more
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The logic of ionic homeostasis: Cations are for voltage, but not for volume. [PDF]
PLoS Computational Biology, 2019 Neuronal activity is associated with transmembrane ionic redistribution, which can lead to an osmotic imbalance. Accordingly, activity-dependent changes of the membrane potential are sometimes accompanied by changes in intracellular and/or extracellular ...
Andrey V Dmitriev +2 more
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, 2009 It has long been stated that the K(+)-Cl(-) cotransporters (KCCs) are activated during cell swelling through dephosphorylation of their cytoplasmic domains by a protein phosphatase (PP) but that other enzymes are involved by targeting this PP or the KCCs
Simard, Michael G +11 more
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Sex and species differences in epithelial transport in rat and mouse kidneys: Modeling and analysis
Frontiers in Physiology, 2022 The goal of this study was to investigate the functional implications of sex and species differences in the pattern of transporters along nephrons in the rat and mouse kidney, as reported by Veiras et al. (J Am Soc Nephrol 28: 3504–3517, 2017). To do so,
Melissa Maria Stadt +4 more
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Evidence for K‐Cl cotransporter heterodimerization
The FASEB Journal, 2012 In humans, mutations in the gene SLC12A6 which encodes for KCC3 result in an autosomal recessive disease, known as ACCPN (Agenesis of the Corpus Callosum associated with Peripheral Neuropathy). In the present work we focused our efforts in understanding the lethality demonstrated by the homozygosity of the Glu289Gly (E289G ...
Jose Ponce-Coria +2 more
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Frontiers in Molecular Neuroscience, 2021 The activation of chloride (Cl−)permeable gamma (γ)-aminobutyric acid type A(GABAA) receptors induces synaptic inhibition in mature and excitation in immature neurons. This developmental “switch” in GABA function controlled by its polarity depends on the
Wee Meng Lim +9 more
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The Na-K-Cl Co-transporter in astrocyte swelling
, 2010 Ion channels, exchangers and transporters are known to be involved in cell volume regulation. A disturbance in one or more of these systems may result in loss of ion homeostasis and cell swelling.
Norenberg, Michael D +1 more
core +1 more source
Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space. [PDF]
PLoS Computational Biology, 2009 Neuronal stimulation causes approximately 30% shrinkage of the extracellular space (ECS) between neurons and surrounding astrocytes in grey and white matter under experimental conditions.
Ivar Østby +8 more
doaj +1 more source