Results 51 to 60 of about 3,400 (190)
, 1999 This study compares the effects of heat and osmotic stress on heat stress protein (HSP) production while examining the putative protective action of HSPs on modulation of Na+,K+,Cl− and Na+,Pi cotransporters in Madin-Darby canine kidney (MDCK) epithelial
Pavel Hamet +9 more
core +1 more source
Colonic Fluid and Electrolyte Transport 2022: An Update
Cells, 2022 Colonic epithelial cells are responsible for maintaining a delicate balance between luminal secretion and the absorption of fluids and ions. This review aims to discuss and update the model of colonic electrolyte secretion and absorption via the cystic ...
Abel B. Negussie +3 more
doaj +1 more source
Structural and Functional Studies of the K+/Cl- Cotransporter 4 [PDF]
, 2023 Cation-chloride-cotransporters (CCCs) play critical roles in cellular volume regulation, neural development and function, audition, regulation of blood pressure, and renal function.
Reid, Michelle Soto
core
Frontiers in Physiology, 2017 Na+:K+:2Cl− cotransporters (NKCCs) belong to the SLC12A family of cation-coupled Cl− transporters. We investigated whether enamel-producing mouse ameloblasts express NKCCs.
Rozita Jalali +10 more
doaj +1 more source
Beta-Amyloid (Aβ1-42) Increases the Expression of NKCC1 in the Mouse Hippocampus
Molecules, 2022 Alzheimer’s disease (AD) is a neurodegenerative disorder with an increasing need for developing disease-modifying treatments as current therapies only provide marginal symptomatic relief.
Patricia Lam +8 more
doaj +1 more source
Insulin activates furosemide-sensitive K+ and Cl- uptake system in BC3H1 cells
, 1994 Insulin augments the activity of Na(+)-K(+)-adenosinetriphosphatase (ATPase) in skeletal muscles. This study shows that when furosemide- and bumetanide-inhibitable 86Rb+ uptake is measured in the skeletal muscle-like BC3H1 cell line, insulin and insulin ...
Y. Gutman, E. Weil-Maslansky, S. Sasson
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Localization of bumetanide- and thiazide-sensitive Na-K-Cl cotransporters along the rat nephron
, 1996 The present study was undertaken to investigate the mRNA localization of the two major kidney-specific Na-K-Cl transport proteins, the bumetanide-sensitive cotransporter (NKCC2 in rabbit and BSC1 in rat) and the thiazide-sensitive cotransporter (TSC ...
T. Yang +4 more
core +1 more source
The opposing Chloride Cotransporters KCC and NKCC control locomotor activity in constant light and during long days [PDF]
, 2022 Cation chloride cotransporters (CCCs) regulate intracellular chloride ion concentration ([Cl−]i) within neurons, which can reverse the direction of the neuronal response to the neurotransmitter GABA.
Buhl, Edgar +4 more
core +1 more source
Regulation of Intracellular Chloride by Cotransporters in Developing Lateral Superior Olive Neurons
, 1999 The regulatory mechanisms of intracellular Cl−concentration ([Cl−]i) were investigated in the lateral superior olive (LSO) neurons of various developmental stages by taking advantage of gramicidin perforated patch recording mode, which enables neuronal ...
Yasuhiro Kakazu +3 more
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Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain
Cell Reports, 2016 Summary: Chronic neuropathic pain is a debilitating condition that remains difficult to treat. Diminished synaptic inhibition by GABA and glycine and increased NMDA receptor (NMDAR) activity in the spinal dorsal horn are key mechanisms underlying ...
Lingyong Li +6 more
doaj +1 more source