Results 71 to 80 of about 3,400 (190)

Na-K-Cl cotransport in the shark rectal gland. II. Regulation in isolated tubules

, 1992
We examined the binding of [3H]benzmetanide, a potent inhibitor of Na-K-Cl cotransport, to secretory tubules isolated from dogfish shark rectal glands. Specific binding increased dramatically (from 3 to 40 pmol/mg protein) when the tubules were exposed ...
C. Lytle, B. Forbush
core   +1 more source

The Importance of Connexin 43 in Enamel Development and Mineralization

Frontiers in Physiology, 2018
During enamel development, formation of hydroxyapatite crystals and regulation of pH in the enamel matrix require massive transport of ions. Both ameloblasts and adjacent dental epithelial cells in the stellate reticulum co-express several transmembrane ...
Sali Al-Ansari, Rozita Jalali, Lilian I. Plotkin, Lilian I. Plotkin, Lilian I. Plotkin, Antonius L. J. J. Bronckers, Pamela DenBesten, Yan Zhang, Judith E. Raber-Durlacher, Judith E. Raber-Durlacher, Jan de Lange, Frederik R. Rozema, Frederik R. Rozema   +12 more
doaj   +1 more source

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

, 2009
SummaryModulation of intracellular chloride concentration ([Cl−]i) plays a fundamental role in cell volume regulation and neuronal response to GABA. Cl− exit via K-Cl cotransporters (KCCs) is a major determinant of [Cl−]I; however, mechanisms governing ...
Gulcicek, Erol E., Tanis, Jessica E., Joiner, Clinton H., Stone, Kathryn L., Wu, Dianqing, Lifton, Richard P., Risinger, Mary, Forbush, Biff, Maksimova, Yelena D., Hodson, Caleb A., Zhang, Junhui, Gallagher, Patrick G., Rinehart, Jesse, Pan, Weijun, Colangelo, Christopher M.   +14 more
core   +1 more source

Canonical Bcl-2 Motifs of the Na+/K+ Pump Revealed by the BH3 Mimetic Chelerythrine: Early Signal Transducers of Apoptosis?

Cellular Physiology and Biochemistry, 2013
Background/Aims: Chelerythrine [CET], a protein kinase C [PKC] inhibitor, is a prop-apoptotic BH3-mimetic binding to BH1-like motifs of Bcl-2 proteins.
Peter K. Lauf, Judith Heiny, Jarek Meller, Michael A. Lepera, Leonid Koikov, Gerald M. Alter, Thomas L. Brown, Norma C. Adragna   +7 more
doaj   +1 more source

Expression of K +-Cl - cotransporters in the α-cells of rat endocrine pancreas

, 2004
The expression of K +-Cl - cotransporters (KCC) was examined in pancreatic islet cells. mRNA for KCC1, KCC3a, KCC3b and KCC4 were identified by RT-PCR in islets isolated from rat pancreas.
Alper, S. L., Alper, Seth L., Roussa, Eleni, Le Rouzic, Philippe, Thevenod, F., Brown, P. D., Best, Len, Thévenod, Frank, Brown, Peter D., Best, L., Davies, Sarah L., Le Rouzic, P.   +11 more
core   +1 more source

K⁺‐Cl⁻ cotransport: ‘to be or not to be’ oxygen sensitive

The Journal of Physiology, 1998
Under 20 years ago, K+-Cl− cotransport (Cot) was discovered in red blood cells after hyposmotic cell swelling (Dunham & Ellory, 1981) and cellular thiol modification (Lauf & Theg, 1980), and later shown to be electroneutral (Kaji, 1993; Lauf & Adragna, 1996).
openaire   +3 more sources

Regulatory Volume Decrease in Neural Precursor Cells: Taurine Efflux and Gene Microarray Analysis

Cellular Physiology and Biochemistry, 2014
Background/Aims: Neural stem/ progenitor cells (NPCs) endure important changes in cell volume during growth, proliferation and migration. As a first approach to know about NPC response to cell volume changes, the Regulatory Volume Decrease (RVD ...
Reyna Hernández-Benítez, Adriana Sedeño-Cortés, Gerardo Ramos-Mandujano, Herminia Pasantes-Morales   +3 more
doaj   +1 more source

Functional and molecular characterization of the K-Cl cotransporter ofXenopus laevisoocytes

, 2001
The K-Cl cotransporters (KCCs) have a broad range of physiological roles, in a number of cells and species. We report here that Xenopus laevis oocytes express a K-Cl cotransporter with significant functional and molecular similarity to mammalian KCCs ...
Norma Vázquez, David B. Mount, Adriana Mercado, Patricia Meade, Paola de los Heros, Gerardo Gamba   +5 more
core   +1 more source

Cation-chloride cotransporters and GABA-ergic innervation in the human epileptic hippocampus

, 2013
Intracellular chloride concentration, [Cl-]i, determines the polarity of GABAA-induced neuronal Cl- currents. In neurons, [Cl-]i is set by the activity of Na+, K+, 2Cl- cotransporters (NKCC) such as NKCC1, which physiologically accumulate Cl- in the cell,
Méndez, Pablo, DeFelipe, Javier, Álvarez-Leefmans, F. J., Muñoz Céspedes, Alberto   +3 more
core   +2 more sources

Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue

, 2000
K-Cl cotransporters (KCC) play fundamental roles in ionic and osmotic homeostasis. To date, four mammalian KCC genes have been identified. KCC2 is expressed exclusively in neurons. Injection of Xenopus oocytes with KCC2 cRNA induced a 20-fold increase in
Thomas D. Singer, Eric Delpire, Kevin Strange, Rebecca Morrison   +3 more
core   +1 more source