Results 81 to 90 of about 3,400 (190)

Sevoflurane-induced regulation of NKCC1/KCC2 phosphorylation through activation of Spak/OSR1 kinase and cognitive impairment in ischemia-reperfusion injury in rats

Heliyon
The occurrence of excitotoxic damage caused by cerebral ischemia-reperfusion (I/R) injury is closely linked to a decrease in central inhibitory function, in which the concentration of chloride inside the cells ([Cl−]i) plays a crucial role.
Yuefeng Wang, Yuanyu Zhang, Wei Yu, Mengjuan Dong, Pingping Cheng, Ye Wang   +5 more
doaj   +1 more source

Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia

Molecular Pain, 2007
Background The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult.
Cervero Fernando, Entrena Jose M, Price Theodore J, Pitcher Mark H   +3 more
doaj   +1 more source

[Pathophysiological aspects of K+: Cl- cotransporters].

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 2014
The K+:Cl- cotransporters or KCCs are membrane proteins that move K+ and Cl- ions across the membrane without changing the transmembrane potential. KCCs belong to the SLC12 (Solute Carrier Family 12) family of electroneutral cation-chloride cotransporters (CCC), and they are secondary active ion transporters because use the established gradients from ...
Adriana, Mercado, Zesergio, Melo
openaire   +1 more source

Phospho-dependent modulation of potassium chloride co-transporter KCC2

, 2009
The neuronal-specific potassium chloride co-transporter 2, KCC2, is a major chloride extruder in brain. The expression of KCC2 during neuronal development is fundamental to the switch of GABAergic response from excitatory to inhibitory. Malfunction of
Lee, H.C.
core  

Structural basis for human NKCC1 inhibition by loop diuretic drugs

The EMBO Journal
Na+–K+–Cl− cotransporters functions as an anion importers, regulating trans-epithelial chloride secretion, cell volume, and renal salt reabsorption. Loop diuretics, including furosemide, bumetanide, and torsemide, antagonize both NKCC1 and NKCC2, and are
Yongxiang Zhao, Pietro Vidossich, Biff Forbush, Junfeng Ma, Jesse Rinehart, Marco De Vivo, Erhu Cao   +6 more
doaj   +1 more source

Inflammatory Pathways of Sulfonamide Diuretics: Insights into SLC12A Cl– Symporters and Additional Targets

Cellular Physiology and Biochemistry
Thiazide, thiazide-like, and loop diuretics are primarily known for inhibiting members of the SLC12A family of Cl– transporters, which include the Na+Cl– cotransporter (NCC), Na+K+2Cl– cotransporters (NKCC1 and NKCC2) and K+Cl– symporters (KCC1-4). While
Mauricio Di Fulvio
doaj   +1 more source

Vhc1, a novel transporter belonging to the family of electroneutral cation–Cl− cotransporters, participates in the regulation of cation content and morphology of Saccharomyces cerevisiae vacuoles

, 2013
Cation–Cl− cotransporters (CCCs) are integral membrane proteins which catalyze the coordinated symport of Cl− with Na+ and/or K+ ions in plant and mammalian cells.
Kinclova-Zimmermannova, Olga, Sychrova, Hana, Petrezselyova, Silvia   +2 more
core   +1 more source

Cation-chloride cotransporters in neuronal development, plasticity and disease

, 2014
Electrical activity in neurons requires a seamless functional coupling between plasmalemmal ion channels and ion transporters. Although ion channels have been studied intensively for several decades, research on ion transporters is in its infancy.
Juha Voipio, Puskarjov, Martin, John A. Payne, Kaila, Kai, Price, Theodore J, Payne, John A, Kai Kaila, Theodore J. Price, Martin Puskarjov, Voipio, Juha   +9 more
core   +1 more source

Molecular insights into the normal operation, regulation, and multisystemic roles of K⁺-Cl⁻ cotransporter 3 (KCC3)

, 2017
Long before the molecular identity of the Na+-dependent K+-Cl− cotransporters was uncovered in the mid-nineties, a Na+-independent K+-Cl− cotransport system was also known to exist.
J. L. Lavoie, Mac-Way, Fabrice, A. P. Garneau, P. Isenring, Garneau, Alexandre, Marcoux, Andrée-Anne, Isenring, Paul, A. A. Marcoux, Lavoie, Julie, F. Mac-Way, Frenette-Cotton, Rachelle, R. Frenette-Cotton   +11 more
core   +1 more source

Proinflammatory cytokines modify Ca2+ signaling and induce an apoptotic lipidome in murine small intestinal organoids

Frontiers in Physiology
BackgroundInflammatory bowel diseases (IBD) are associated with elevated levels of proinflammatory cytokines exerting a detrimental effect on the intestinal epithelium.
Svenja Mareike Pauer, Alina Schindler, Parviz Ghezellou, Parviz Ghezellou, Parviz Ghezellou, Bernhard Spengler, Martin Diener, Jasmin Ballout   +7 more
doaj   +1 more source