Results 61 to 70 of about 3,400 (190)

Heterologous Expression of Aedes aegypti Cation Chloride Cotransporter 2 (aeCCC2) in Xenopus laevis Oocytes Induces an Enigmatic Na+/Li+ Conductance

Insects, 2019
The yellow fever mosquito Aedes aegypti possesses three genes encoding putative Na+-coupled cation chloride cotransporters (CCCs): aeNKCC1, aeCCC2, and aeCCC3. To date, none of the aeCCCs have been functionally characterized.
Megha Kalsi, Christopher Gillen, Peter M. Piermarini   +2 more
doaj   +1 more source

Modeling glial contributions to seizures and epileptogenesis: cation-chloride cotransporters in Drosophila melanogaster.

PLoS ONE, 2014
Flies carrying a kcc loss-of-function mutation are more seizure-susceptible than wild-type flies. The kcc gene is the highly conserved Drosophila melanogaster ortholog of K+/Cl- cotransporter genes thought to be expressed in all animal cell types.
Zeid M Rusan, Olivia A Kingsford, Mark A Tanouye   +2 more
doaj   +1 more source

Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter

, 1999
We isolated and characterized a novel K-Cl cotransporter, KCC3, from human placenta. The deduced protein contains 1,150 amino acids. KCC3 shares 75–76% identity at the amino acid level with human, pig, rat, and rabbit KCC1 and 67% identity with rat KCC2.
Paul J. Logue, Fadi N. Makhlouf, Frederick H. Wilson, Joanne E. Race, Philip B. Dunham, Eli J. Holtzman   +5 more
core   +1 more source

GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice. [PDF]

PLoS ONE, 2011
Cortical GABAergic interneurons originate from ganglionic eminences and tangentially migrate into the cortical plate at early developmental stages.
Hiroyuki Inada, Miho Watanabe, Taku Uchida, Hitoshi Ishibashi, Hiroaki Wake, Tomomi Nemoto, Yuchio Yanagawa, Atsuo Fukuda, Junichi Nabekura   +8 more
doaj   +1 more source

Vasoactive intestinal peptide stimulates active K+ transport and Na(+)-K(+)-Cl- cotransport in HT-29 cells

, 1990
Regulation of active K+ influx and Na(+)-K(+)-Cl- cotransport activity in HT-29 cells by vasoactive intestinal peptide (VIP) was investigated. Both active K+ influx, defined as the ouabain-sensitive component, and Na(+)-K(+)-Cl- cotransport, defined as ...
D. W. Bollinger, C. C. Franklin, J. T. Turner, H. D. Kim   +3 more
core   +1 more source

Chemical crosslinking studies with the mouse Kcc1 K–Cl cotransporter [PDF]

Blood Cells, Molecules, and Diseases, 2009
Oligomerization, function, and regulation of unmodified mouse Kcc1 K-Cl cotransporter were studied by chemical crosslinking. Treatment of Xenopus oocytes and 293T cells expressing K-Cl cotransporter Kcc1 with several types of chemical cross-linkers shifted Kcc1 polypeptide to higher molecular weight forms. More extensive studies were performed with the
Sabina, Casula, Alexander S, Zolotarev, Alan K, Stuart-Tilley, Sabine, Wilhelm, Boris E, Shmukler, Carlo, Brugnara, Seth L, Alper   +6 more
openaire   +2 more sources

Synopsis of the 48th Annual Meeting of the Lake Cumberland Biological Transport Group and the Second Biannual Meeting of the Pendrin Consortium

Cellular Physiology and Biochemistry, 2013
Ion transporters are the molecular basis for ion homeostasis of the cell and the whole organism. The anion exchanger pendrin is only one of a number of examples where a complete or partial loss of function and/or deregulation of expression of ion ...
Silvia Dossena, Charity Nofziger, Rossana Morabito, Norma C. Adragna, Markus Paulmichl   +4 more
doaj   +1 more source

Modulation of K(+)‐Cl‐ cotransport in equine red blood cells [PDF]

Experimental Physiology, 1994
Potassium transport was measured in equine red blood cells, using 86Rb+ influx as a convenient assay. A significant component of volume‐ and pH‐sensitive K(+)‐Cl‐ cotransport to the overall K+ flux was observed in all blood samples studied, although fluxes were variable between animals, and within individuals when measured at intervals over a period of
J S, Gibson, H, Godart, J C, Ellory, H, Staines, N A, Honess, A R, Cossins   +5 more
openaire   +2 more sources

Cloning, characterization, and gene organization of K-Cl cotransporter from pig and human kidney andC. elegans

, 1998
We isolated and characterized the cDNAs for the human, pig, and Caenorhabditis elegansK-Cl cotransporters. The pig and human homologs are 94% identical and contain 1,085 and 1,086 amino acids, respectively. The deduced protein of the C.
Sumit Kumar, Paul J. Logue, Sara J. Erickson, Carol A. Faaland, Shiv Kumar, Philip B. Dunham, Fern Warner, Gesa Ricken, Jeremy Waldman, Eli J. Holtzman   +9 more
core   +1 more source

Off-Label Use of Bumetanide for Brain Disorders: An Overview

Frontiers in Neuroscience, 2019
Bumetanide (BTN or BUM) is a FDA-approved potent loop diuretic (LD) that acts by antagonizing sodium-potassium-chloride (Na-K-Cl) cotransporters, NKCC1 (SLc12a2) and NKCC2.
Shivani C. Kharod, Seok Kyu Kang, Shilpa D. Kadam, Shilpa D. Kadam   +3 more
doaj   +1 more source