Results 1 to 10 of about 3,123 (161)

The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies

Journal of Pharmaceutical Analysis, 2023
The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises potassium chloride cotransporters (KCCs, e.g. KCC1, KCC2, KCC3, and KCC4)-mediated Cl− extrusion, and sodium potassium chloride cotransporters (N[K]CCs, NKCC1, NKCC2,
Shiyao Zhang, Nur Farah Meor Azlan, Lingjun Jie   +2 more
exaly   +3 more sources

Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease

Cells, 2020
The SLC12 family of cation-chloride-cotransporters (CCCs) is comprised of potassium chloride cotransporters (KCCs), which mediate Cl− extrusion and sodium-potassium chloride cotransporters (N[K]CCs), which mediate Cl− loading.
Nur Farah Meor Azlan, Jinwei Zhang, Zhang Jinwei   +2 more
exaly   +3 more sources

K-Cl cotransporters, cell volume homeostasis, and neurological disease. [PDF]

Trends Mol Med, 2015
K(+)-Cl(-) cotransporters (KCCs) were originally characterized as regulators of red blood cell (RBC) volume. Since then, four distinct KCCs have been cloned, and their importance for volume regulation has been demonstrated in other cell types. Genetic models of certain KCCs, such as KCC3, and their inhibitory WNK-STE20/SPS1-related proline/alanine-rich
Kahle KT, Khanna AR, Alper SL, Adragna NC, Lauf PK, Sun D, Delpire E.   +6 more
europepmc   +6 more sources

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters [PDF]

FEBS Open Bio
The cation‐chloride cotransporter (CCC) family includes ion symporters that cotransport monovalent cations and Cl−, playing a crucial role in controlling cytoplasmic ion content.
Satoshi Fudo, Marina Verkhovskaya, Coralie Di Scala, Claudio Rivera, Tommi Kajander   +4 more
doaj   +2 more sources

Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. [PDF]

Biochim Biophys Acta, 2010
Precise regulation of the intracellular concentration of chloride [Cl-]i is necessary for proper cell volume regulation, transepithelial transport, and GABA neurotransmission. The Na-K-2Cl (NKCCs) and K-Cl (KCCs) cotransporters, related SLC12A transporters mediating cellular chloride influx and efflux, respectively, are key determinants of [Cl-]i in ...
Kahle KT, Rinehart J, Lifton RP.
europepmc   +3 more sources

Structural Pharmacology of Cation-Chloride Cotransporters

Membranes, 2022
Loop and thiazide diuretics have been cornerstones of clinical management of hypertension and fluid overload conditions for more than five decades. The hunt for their molecular targets led to the discovery of cation-chloride cotransporters (CCCs) that ...
Yongxiang Zhao, Erhu Cao
exaly   +3 more sources

Cation-Chloride Cotransporters, Na/K Pump, and Channels in Cell Water and Ion Regulation: In silico and Experimental Studies of the U937 Cells Under Stopping the Pump and During Regulatory Volume Decrease

Frontiers in Cell and Developmental Biology, 2021
Cation-coupled chloride cotransporters play a key role in generating the Cl– electrochemical gradient on the cell membrane, which is important for regulation of many cellular processes.
Valentina E Yurinskaya, Alexey A Vereninov, Yurinskaya Valentina E   +2 more
exaly   +3 more sources

Balance of Na+, K+, and Cl– Unidirectional Fluxes in Normal and Apoptotic U937 Cells Computed With All Main Types of Cotransporters

Frontiers in Cell and Developmental Biology, 2020
Fluxes of monovalent ions through the multiple pathways of the plasma membrane are highly interdependent, and their assessment by direct measurement is difficult or even impossible.
Valentina E Yurinskaya, Alexey A Vereninov, Yurinskaya Valentina E   +2 more
exaly   +3 more sources

Expression and Purification of the Human Cation-chloride Cotransporter KCC1 from HEK293F Cells for Structural Studies

Bio-Protocol, 2021
Cation-chloride cotransporters (CCCs) mediate the coupled, electroneutral symport of cations such as Na+ and/or K+ with chloride across membrane.
Si Liu, Jiangtao Guo
doaj   +1 more source

Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide

Nature Communications, 2022
Loop diuretics including bumetanide inhibit Na+-K+-Cl−-cotransporters (NKCCs) and are used for the treatment of edema and hypertension. Here, Zhao et. al.
Yongxiang Zhao, Kasturi Roy, Pietro Vidossich, Laura Cancedda, Marco De Vivo, Biff Forbush, Erhu Cao   +6 more
doaj   +1 more source