Results 121 to 130 of about 352,958 (260)

Loop Diuretic and Ion-binding Residues Revealed by Scanning Mutagenesis of Transmembrane Helix 3 (TM3) of Na-K-Cl Cotransporter (NKCC1)*

Journal of Biological Chemistry, 2012
Background: Na-K-Cl cotransporters (NKCCs) are essential in chloride homeostasis and salt transport. Results: Mutations in NKCC1 transmembrane domain 3 (TM3) alter transport activity, ion binding, and inhibitor affinities. Conclusion: This demonstrates a
Suma Somasekharan, Jessica E. Tanis, B. Forbush   +2 more
semanticscholar   +1 more source

A Mathematical Theory for Vibrational Levels Associated with Hydrogen Bonds II: The Non--Symmetric Case [PDF]

, 2008
We propose an alternative to the usual time--independent Born--Oppenheimer approximation that is specifically designed to describe molecules with non--symmetrical hydrogen bonds. In our approach, the masses of the hydrogen nuclei are scaled differently from those of the heavier nuclei, and we employ a specialized form for the electron energy level ...
arxiv   +1 more source

Population profile and glycemic control following initiation or switch of injectable therapies in Tianjin, China: A real‐world retrospective cohort study of adults with type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
This real‐world retrospective study of individuals with type 2 diabetes receiving injectable therapies in Tianjin, China, demonstrates the participant characteristics, treatment patterns and effectiveness of initiating and switching injectable therapy in this population.
Qiumei Zhang, Yaqing Fan, Xixi Liu, Minlu Zhang, Jiewen Zhang, Qin Du, Lei Kang, Liming Chen   +7 more
wiley   +1 more source

Regulatory Volume Decrease in Neural Precursor Cells: Taurine Efflux and Gene Microarray Analysis

Cellular Physiology and Biochemistry, 2014
Background/Aims: Neural stem/ progenitor cells (NPCs) endure important changes in cell volume during growth, proliferation and migration. As a first approach to know about NPC response to cell volume changes, the Regulatory Volume Decrease (RVD ...
Reyna Hernández-Benítez, Adriana Sedeño-Cortés, Gerardo Ramos-Mandujano, Herminia Pasantes-Morales   +3 more
doaj   +1 more source

Role of an apical K,Cl cotransporter in urine formation by renal tubules of the yellow fever mosquito (Aedes aegypti).

American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2011
The K,Cl cotransporters (KCCs) of the SLC12 superfamily play critical roles in the regulation of cell volume, concentrations of intracellular Cl(-), and epithelial transport in vertebrate tissues.
P. Piermarini, Rebecca M Hine, Matthew Schepel, J. Miyauchi, K. Beyenbach   +4 more
semanticscholar   +1 more source

Wavelet analysis of corneal endothelial electrical potential difference reveals cyclic operation of the secretory mechanism [PDF]

arXiv, 2011
There is evidence that the electrical potential difference of corneal endothelium (TEPD) is related electro-osmotically to fluid transport. Hence, determination of the TEPD would serve as a measure of the fluid movement. The oscillatory nature of the TEPD has been recognized recently using the Fourier transform; the oscillations of the highest ...
arxiv  

The apical mucus layer alters the pharmacological properties of the airway epithelium

The Journal of Physiology, EarlyView.
Abstract figure legend In the airway epithelium, the cAMP‐activated cystic fibrosis transmembrane conductance regulator (CFTR) channel is a major pathway for chloride secretion. Its activity can potentially be evaluated by measuring the extent of chloride flux inhibition elicited by CFTR blockers, such as CFTRinh‐172 and PPQ‐102.
Daniela Guidone, Martina de Santis, Emanuela Pesce, Valeria Capurro, Nicoletta Pedemonte, Luis J. V. Galietta   +5 more
wiley   +1 more source

Propionic Acidemia‐Induced Proarrhythmic Electrophysiological Alterations in Human iPSC‐Derived Cardiomyocytes

Journal of Inherited Metabolic Disease, Volume 48, Issue 3, May 2025.
ABSTRACT Propionic acidemia (PA) is a metabolic disorder caused by a deficiency of the mitochondrial enzyme propionyl‐CoA carboxylase (PCC) due to mutations in the PCCA or PCCB genes, which encode the two PCC subunits. PA may lead to several types of cardiomyopathy and has been linked to cardiac electrical abnormalities such as QT interval prolongation,
Anabel Cámara‐Checa, Mar Álvarez, Josu Rapún, Sara Pérez‐Martín, Roberto Núñez‐Fernández, Marcos Rubio‐Alarcón, Teresa Crespo‐García, Lourdes R. Desviat, Eva Delpón, Ricardo Caballero, Eva Richard   +10 more
wiley   +1 more source

Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia

Molecular Pain, 2007
Background The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult.
Cervero Fernando, Entrena Jose M, Price Theodore J, Pitcher Mark H   +3 more
doaj   +1 more source

Association of normal range of urinary albumin‐to‐creatinine ratio with all‐cause mortality among diabetic adults with preserved kidney function: National Health and Nutrition Examination Survey (NHANES) 2003–2018

Diabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2670-2678, May 2025.
Abstract Aim To ascertain the connection between normal‐range urinary albumin‐to‐creatinine ratio (UACR) and all‐cause mortality (ACM) among diabetic adults with preserved eGFR. Methods We used data from the 2003–2018 National Health and Nutrition Examination Survey.
Xiaoxia Pang, Wenchao Dan, Lan Lin, Huimei Li, Xiangrong Rao, Shen Li   +5 more
wiley   +1 more source