Results 151 to 160 of about 3,400 (190)

Erythrocyte K-Cl cotransport: properties and regulation

American Journal of Physiology-Cell Physiology, 1992
Erythrocytes possess a Cl-dependent, Na-independent K transport system cotransporting K and Cl in a 1:1 stoichiometry that is membrane potential independent. This K-Cl cotransporter is stimulated by cell swelling, acidification, Mg depletion, and thiol modification.
Lauf, Peter K., Bauer, J., Adragna, Norma C., Fujise, H., Zade-Oppen, A. M.M., Kyoo Hai Ryu, Hai Ryu, Delpire, E.   +6 more
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The structure of Na+-K+-Cl− cotransporter 1

Nature Reviews Nephrology, 2019
A recent study reports the first high-resolution, cryo-electron microscopy-based structure of zebrafish Na+-K+-Cl− cotransporter 1 (NKCC1). This structure provides important insights into the determinants of ion translocation by NKCC1 and other cation-Cl− cotransporters such as NKCC2.
Alexandre P. Garneau, Paul Isenring
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K-Cl cotransporter expression in the human kidney

American Journal of Physiology-Cell Physiology, 1998
The K-Cl cotransporter protein KCC1 is a membrane transport protein that mediates the coupled, electroneutral transport of K and Cl across plasma membranes. The precise cell type(s) in the kidney that express the K-Cl cotransporter have remained unknown.
H, Liapis, M, Nag, D M, Kaji
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CIP1 is an activator of the K+–Cl− cotransporter KCC2

Biochemical and Biophysical Research Communications, 2009
In most neurons, efficient setting of the intracellular Cl(-)-concentration requires the coordinated regulation of the Cl(-)-inward transporter NKCC1 and the Cl(-)-outward transporter KCC2. Previously, the cation-chloride cotransporter interacting protein 1 (CIP1) was shown to inactivate NKCC1. Here, we investigated its role for KCC2 activity. After co-
Meike, Wenz, Anna-Maria, Hartmann, Eckhard, Friauf, Hans Gerd, Nothwang   +3 more
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The Na-K-Cl Cotransporter of Secretory Epithelia

Annual Review of Physiology, 2000
▪ Abstract  The Na-K-Cl cotransporters are a class of ion transport proteins that transport Na, K, and Cl ions into and out of cells in an electrically neutral manner, in most cases with a stoichiometry of 1Na:1K:2Cl. To date, two Na-K-Cl cotransporter isoforms have been identified: NKCC1, which is present in a wide variety of secretory epithelia and ...
M, Haas, B, Forbush
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Effects of okadaic acid and intracellular Cl- on Na(+)-K(+)-Cl- cotransport

American Journal of Physiology-Cell Physiology, 1995
The Na(+)-K(+)-Cl- cotransporter of the squid giant axon requires ATP and is inhibited by intracellular Cl- (Cli-) in a concentration-dependent manner ([Cl-]i > or = 200 mM completely inhibits the cotransporter). In the present study we address the question of whether inhibition of cotransport by Cli- is due to a Cl(i-)-induced increase of protein ...
A A, Altamirano, G E, Breitwieser, J M, Russell   +2 more
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Role of Na/K/Cl cotransport in astrocytes

Canadian Journal of Physiology and Pharmacology, 1992
The kinetic characterization of the Na/K/Cl cotransport of cultured astrocytes and evidence for its involvement in volume regulation and K+ net uptake during K+ clearance are reviewed. Emphasis is put on experimental evidence for a proposed sodium cycle in astrocytes; this cycle involves a Na+–K+ ATPase that is stimulated by both a high external K ...
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Asymmetry of Na-K-Cl cotransport in human erythrocytes

American Journal of Physiology-Cell Physiology, 1988
The Na-K-Cl cotransport system in human erythrocytes was studied by measuring net influxes and effluxes of Na and K. The influx of K was shown to be stimulated by Na and the influx of Na was stimulated by K, satisfying the fundamental criterion of cotransport.
G R, Kracke, M A, Anatra, P B, Dunham
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Molecular Physiology of Mammalian K+-CL− Cotransporters

2006
Potassium-chloride (K-Cl) cotransport is a major pathway for the coupled, electroneutral exit of K and Cl from perhaps all mammalian cells. This transport activity is mediated by KCC proteins encoded by four genes in the SLC12 family of electroneutral cation-chloride cotransporters.
Adriana, Mercado, Gerardo, Gamba, David B, Mount   +2 more
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Regulation of renal Na-(K)-Cl cotransporters by vasopressin

Pflügers Archiv - European Journal of Physiology, 2017
Vasopressin (AVP) induces antidiuresis, thus playing an essential role in body water and electrolyte homeostasis. Its antidiuretic effects are mediated chiefly by V2 vasopressin receptors (V2R) expressed along the distal nephron and collecting duct epithelia.
Sebastian Bachmann, Kerim Mutig
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