Results 221 to 230 of about 352,958 (260)

Regulation of renal Na-(K)-Cl cotransporters by vasopressin

Pflügers Archiv - European Journal of Physiology, 2017
Vasopressin (AVP) induces antidiuresis, thus playing an essential role in body water and electrolyte homeostasis. Its antidiuretic effects are mediated chiefly by V2 vasopressin receptors (V2R) expressed along the distal nephron and collecting duct epithelia.
S. Bachmann, K. Mutig
semanticscholar   +4 more sources

The Na-K-Cl cotransporter of secretory epithelia.

Annual Review of Physiology, 2000
The Na-K-Cl cotransporters are a class of ion transport proteins that transport Na, K, and Cl ions into and out of cells in an electrically neutral manner, in most cases with a stoichiometry of 1Na:1K:2Cl. To date, two Na-K-Cl cotransporter isoforms have
M. Haas, B. Forbush
semanticscholar   +4 more sources

The structure of Na+-K+-Cl− cotransporter 1 [PDF]

Nature Reviews Nephrology, 2019
A recent study reports the first high-resolution, cryo-electron microscopy-based structure of zebrafish Na+-K+-Cl− cotransporter 1 (NKCC1). This structure provides important insights into the determinants of ion translocation by NKCC1 and other cation-Cl− cotransporters such as NKCC2.
Paul Isenring, Alexandre P. Garneau, Alexandre P. Garneau   +2 more
openaire   +2 more sources

Phosphoregulation of K+‐Cl− cotransporters during cell swelling: Novel insights

Journal of Cellular Physiology, 2018
The K+‐Cl− cotransporters (KCCs) belong to the cation‐Cl− cotransporter family and consist of four isoforms and many splice variants. Their main role is to promote electroneutral efflux of K+ and Cl− ions across the surface of many cell types and ...
R. Frenette‐Cotton, A. Marcoux, A. P. Garneau, Micheline Noel, P. Isenring   +4 more
semanticscholar   +1 more source

Localization of bumetanide- and thiazide-sensitive Na-K-Cl cotransporters along the rat nephron.

American Journal of Physiology, 1996
The present study was undertaken to investigate the mRNA localization of the two major kidney-specific Na-K-Cl transport proteins, the bumetanide-sensitive cotransporter (NKCC2 in rabbit and BSC1 in rat) and the thiazide-sensitive cotransporter (TSC ...
Tianxin Yang, Yuning G. Huang, I. Singh, J. Schnermann, J. Briggs   +4 more
semanticscholar   +1 more source

Properties and diversity of (Na-K-Cl) cotransporters.

Annual Review of Physiology, 1989
A specific pathway that mediates the coupled, electrically neutral transport of Na, K, and Cl ions across cell membranes is present in a wide variety of animal tissues, and appears to serve a number of different physiological functions.
M. Haas
semanticscholar   +1 more source

WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters.

Physiology, 2006
Precise control of cellular Cl(-) transport is necessary for many fundamental physiological processes. For example, the intracellular concentration of Cl(-), fine-tuned through the coordinated action of cellular Cl(-) influx and efflux mechanisms ...
K. Kahle, J. Rinehart, A. Ring, I. Giménez, G. Gamba, S. Hebert, R. Lifton   +6 more
semanticscholar   +1 more source

K-Cl cotransporter expression in the human kidney

American Journal of Physiology-Cell Physiology, 1998
The K-Cl cotransporter protein KCC1 is a membrane transport protein that mediates the coupled, electroneutral transport of K and Cl across plasma membranes. The precise cell type(s) in the kidney that express the K-Cl cotransporter have remained unknown.
Helen Liapis, M. Nag, Deepak M. Kaji
openaire   +3 more sources

Erythrocyte K-Cl cotransport: properties and regulation

American Journal of Physiology-Cell Physiology, 1992
Erythrocytes possess a Cl-dependent, Na-independent K transport system cotransporting K and Cl in a 1:1 stoichiometry that is membrane potential independent. This K-Cl cotransporter is stimulated by cell swelling, acidification, Mg depletion, and thiol modification.
Kyoo Hai Ryu, H. Fujise, A. M. M. Zade-Oppen, Norma C. Adragna, J. Bauer, Eric Delpire, Peter K. Lauf   +6 more
openaire   +3 more sources

WNK4 Kinase is a Negative Regulator of K+‐Cl− Cotransporters

AJP - Renal Physiology, 2007
WNK kinases (with no lysine kinase(K)) are regulators of several membrane transport proteins in which these kinases act as a molecular switches that coordinate the activity of several players. Members of the Solute Carrier Family number 12 are one of the
T. Garzon-Muvdi, José Ponce‐Coria, Diana Pacheco‐Alvarez, K. Gagnon, N. Vázquez, Erika Moreno, E. Delpire, G. Gamba   +7 more
semanticscholar   +1 more source