Results 231 to 240 of about 352,958 (260)

CIP1 is an activator of the K+–Cl− cotransporter KCC2

Biochemical and Biophysical Research Communications, 2009
In most neurons, efficient setting of the intracellular Cl(-)-concentration requires the coordinated regulation of the Cl(-)-inward transporter NKCC1 and the Cl(-)-outward transporter KCC2. Previously, the cation-chloride cotransporter interacting protein 1 (CIP1) was shown to inactivate NKCC1. Here, we investigated its role for KCC2 activity. After co-
Anna-Maria Hartmann, Meike Wenz, Hans Gerd Nothwang, Eckhard Friauf   +3 more
openaire   +3 more sources

Molecular mechanisms and regulation of furosemide-sensitive Na–K–Cl cotransporters

Current opinion in nephrology and hypertension, 2006
Purpose of reviewRelevant advances towards understanding how furosemide-sensitive Na–K–Cl cotransporters (NKCC) are regulated by alternative splicing, phosphorylation and membrane expression have been made, which are critical to comprehending the role of
I. Giménez
semanticscholar   +1 more source

Effects of okadaic acid and intracellular Cl- on Na(+)-K(+)-Cl- cotransport

American Journal of Physiology-Cell Physiology, 1995
The Na(+)-K(+)-Cl- cotransporter of the squid giant axon requires ATP and is inhibited by intracellular Cl- (Cli-) in a concentration-dependent manner ([Cl-]i > or = 200 mM completely inhibits the cotransporter). In the present study we address the question of whether inhibition of cotransport by Cli- is due to a Cl(i-)-induced increase of protein ...
G. E. Breitwieser, John M. Russell, A. A. Altamirano   +2 more
openaire   +3 more sources

Functional comparison of renal Na-K-Cl cotransporters between distant species.

American Journal of Physiology - Cell Physiology, 2003
In the shark (sa), two variants of the renal Na-K-Cl cotransporter (saNKCC2A and saNKCC2F) are produced by alternative splicing of the second transmembrane domain (tm(2)).
E. Gagnon, B. Forbush, L. Caron, P. Isenring   +3 more
semanticscholar   +1 more source

Molecular Physiology of Mammalian K+-CL− Cotransporters

2006
Potassium-chloride (K-Cl) cotransport is a major pathway for the coupled, electroneutral exit of K and Cl from perhaps all mammalian cells. This transport activity is mediated by KCC proteins encoded by four genes in the SLC12 family of electroneutral cation-chloride cotransporters.
Adriana Mercado, David B. Mount, Gerardo Gamba   +2 more
openaire   +2 more sources

Expression of aquaporins, vasopressin type 2 receptor, and Na+-K+-Cl– cotransporters in the rat endolymphatic sac

Acta Oto-Laryngologica, 2009
Conclusion. Since many water channels and pumps, such as aquaporin (AQP) 1–4, AQP6–9, vasopressin type 2 receptor (V2-R), Na+-K+-Cl– cotransporter (NKCC) 1, and NKCC2 were expressed in the rat endolymphatic sac, it should play an important role in the ...
M. Nishimura, A. Kakigi, T. Takeda, S. Takeda, K. Doi   +4 more
semanticscholar   +1 more source

Role of Na/K/Cl cotransport in astrocytes

Canadian Journal of Physiology and Pharmacology, 1992
The kinetic characterization of the Na/K/Cl cotransport of cultured astrocytes and evidence for its involvement in volume regulation and K+ net uptake during K+ clearance are reviewed. Emphasis is put on experimental evidence for a proposed sodium cycle in astrocytes; this cycle involves a Na+–K+ ATPase that is stimulated by both a high external K ...
openaire   +3 more sources

Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters.

AJP - Renal Physiology, 2003
The Na(+)-K(+)-Cl(-) cotransporters (NKCCs), which belong to the cation-Cl(-) cotransporter (CCC) family, are able to translocate NH4(+) across cell membranes.
M. Bergeron, Edith Gagnon, B. Wallendorff, J. Lapointe, P. Isenring   +4 more
semanticscholar   +1 more source

The Na-K-Cl cotransporters in the rat cochlea: RT-PCR and partial sequence analysis.

Biochemical and Biophysical Research Communications - BBRC, 1996
Nonsensory epithelial cells of the mammalian cochlea contribute to the production of the endolymph. The presence as well as the function of the Na-K-Cl cotransporter has been suggested, but not yet been proved.
Hiroshi Hidaka, T. Oshima, K. Ikeda, Masayuki Furukawa, Tomonori Takasaka   +4 more
semanticscholar   +1 more source

Asymmetry of Na-K-Cl cotransport in human erythrocytes

American Journal of Physiology-Cell Physiology, 1988
The Na-K-Cl cotransport system in human erythrocytes was studied by measuring net influxes and effluxes of Na and K. The influx of K was shown to be stimulated by Na and the influx of Na was stimulated by K, satisfying the fundamental criterion of cotransport.
Philip B. Dunham, M. A. Anatra, G. R. Kracke   +2 more
openaire   +3 more sources