Results 241 to 250 of about 352,958 (260)

Immunolocalization of Na-K-ATPase, Na-K-Cl and Na-glucose cotransporters in the conjunctival epithelium

Current Eye Research, 2000
Purpose. To investigate possible regional expression of transport systems in the conjunctival epithelium given distinct differences in morphological appearance between the bulbar and palpebral epithelia as well as variations found in the proportions of ...
H. Turner, L. Alvarez, V. Bildin, O. Candia   +3 more
semanticscholar   +1 more source

Regulatory phosphorylation of the secretory Na-K-Cl cotransporter: modulation by cytoplasmic Cl

American Journal of Physiology-Cell Physiology, 1996
The effect of cytoplasmic Cl concentration ([Cl]i) on the activation state ([3H]benzmetanide binding rate) and phosphorylation state (32P incorporation) of the Na-K-Cl cotransporter was evaluated in secretory tubules isolated from the dogfish shark rectal gland.
Christian Lytle, Biff Forbush
openaire   +3 more sources

K+-Cl- Cotransport in Vertebrate Red Cells

2003
The “pump-leak” model of Tosteson and Hoffman (1960) presented an elegant and simple paradigm for regulation of red blood cell (RBC) cation content and volume. It emphasised the importance of a specific, ouabain-sensitive, Na+/K+ pump, driven by ATP, as the primary active transport process for maintaining high intracellular K+, balancing K+ loss ...
J. Clive Ellory, John S. Gibson
openaire   +2 more sources

Na‐K‐Cl Cotransport in Chloride‐transporting Epithelia^a

Annals of the New York Academy of Sciences, 1985
The elasmobranch rectal gland has served as a useful model to study features of Na-K-Cl cotransport that are common to many chloride-transporting epithelia. These include: (1) dependence on a Na+ gradient created by Na-K-ATPase; (2) high intracellular Cl- concentration; (3) characteristic inhibitor profile including inhibition by loop diuretics and ...
Patricio Silva, Franklin H. Epstein
openaire   +3 more sources

The Role of K+-Cl−-Cotransporter-2 in Neuropathic Pain

Neurochemical Research, 2018
The pain sensory system normally functions under a fine balance between excitation and inhibition. When this balance is perturbed for some reason, it leads to neuropathic pain. There is accumulating evidence that attributes this pain generation to specific dysfunctions of the inhibitory system in the spinal cord.
openaire   +3 more sources

Distribution and diversity of Na-K-Cl cotransport proteins: a study with monoclonal antibodies.

American Journal of Physiology, 1995
The Na-K-Cl cotransporter (NKCC) is present in most animal cells where it functions in cell volume homeostasis and epithelial salt transport. We developed six monoclonal antibodies (designated T4, T8, T9, T10, T12, and T14) against a fusion protein ...
Christian Lytle, Jianwei Xu, D. Biemesderfer, B. Forbush   +3 more
semanticscholar   +1 more source

Docking of inhibitors to the structure of the human K‐Cl cotransporter

The FASEB Journal, 2020
Following the release of the cryo‐electron microscopy structure of the human K‐Cl cotransporter, hKCC1, we used a ligand‐protein docking program (Autodock Vina from the Scripps Research Institute) to assess the binding of KCC inhibitors to the K‐Cl cotransporter.
openaire   +2 more sources

Endothelial Na-K-Cl cotransport regulation by tonicity and hormones: phosphorylation of cotransport protein

American Journal of Physiology-Cell Physiology, 1995
The Na-K-Cl cotransport system of vascular endothelial cells plays a central role in maintenance and regulation of intracellular volume. Activity of the cotransporter is modulated both by hormones and by extracellular tonicity. Vasopressin and other hormones that stimulate the endothelial cotransporter act via a Ca- and calmodulin-dependent pathway ...
Martha E O'Donnell, Dandan Sun, Anthony Martinez   +2 more
openaire   +3 more sources

Molecular characterization of the epithelial NaKCl cotransporter isoforms

Current Opinion in Cell Biology, 1995
Recent advances in the molecular characterization of specific isoforms of the Na-K-Cl cotransporter have allowed rapid progress in the study of the structure, function, and regulation of these members of a family of Cl-dependent cation cotransporters.
Bliss Forbush, John A. Payne
openaire   +2 more sources

Characteristics and functions of Na-K-Cl cotransport in epithelial tissues

American Journal of Physiology-Cell Physiology, 1987
This review summarizes our present understanding of Na-K-Cl cotransport and its physiological role in absorption and secretion of electrolytes and water in epithelial tissues. In the past several years an extensive literature about this cotransporter has developed due to its widespread distribution in a variety of cell types and its essential role in ...
H. C. Palfrey, M. Field, Scott M. O'Grady   +2 more
openaire   +3 more sources