Results 241 to 250 of about 6,975 (268)
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Erythrocyte K-Cl cotransport: properties and regulation
American Journal of Physiology-Cell Physiology, 1992Erythrocytes possess a Cl-dependent, Na-independent K transport system cotransporting K and Cl in a 1:1 stoichiometry that is membrane potential independent. This K-Cl cotransporter is stimulated by cell swelling, acidification, Mg depletion, and thiol modification.
P K, Lauf +6 more
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The K–Cl cotransporter-3 in the mammalian kidney
Current Opinion in Nephrology & Hypertension, 2023Purpose of review We recently localized a new K–Cl cotransporters-3 (KCC3) transporter to the apical membrane of type-B intercalated cells. This gives us an opportunity to revisit the roles of the KCC3 in kidney and integrate the new findings to our current knowledge of the biology of the bicarbonate secreting cells.
Mohammed Z, Ferdaus, Eric, Delpire
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The structure of Na+-K+-Cl− cotransporter 1
Nature Reviews Nephrology, 2019A recent study reports the first high-resolution, cryo-electron microscopy-based structure of zebrafish Na+-K+-Cl− cotransporter 1 (NKCC1). This structure provides important insights into the determinants of ion translocation by NKCC1 and other cation-Cl− cotransporters such as NKCC2.
Alexandre P. Garneau, Paul Isenring
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American Journal of Physiology-Cell Physiology, 1994
The Na-K-Cl cotransporters are a class of membrane proteins that transport Na, K, and Cl ions into and out of cells in an electrically neutral manner, in most cases with a stoichiometry of 1Na:1K:2Cl. Na-K-Cl cotransporters are present in a wide variety of cells and tissues, including reabsorptive and secretory epithelia, nerve and muscle cells ...
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The Na-K-Cl cotransporters are a class of membrane proteins that transport Na, K, and Cl ions into and out of cells in an electrically neutral manner, in most cases with a stoichiometry of 1Na:1K:2Cl. Na-K-Cl cotransporters are present in a wide variety of cells and tissues, including reabsorptive and secretory epithelia, nerve and muscle cells ...
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K-Cl cotransporter expression in the human kidney
American Journal of Physiology-Cell Physiology, 1998The K-Cl cotransporter protein KCC1 is a membrane transport protein that mediates the coupled, electroneutral transport of K and Cl across plasma membranes. The precise cell type(s) in the kidney that express the K-Cl cotransporter have remained unknown.
H, Liapis, M, Nag, D M, Kaji
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Molecular Physiology of Mammalian K+-CL− Cotransporters
2006Potassium-chloride (K-Cl) cotransport is a major pathway for the coupled, electroneutral exit of K and Cl from perhaps all mammalian cells. This transport activity is mediated by KCC proteins encoded by four genes in the SLC12 family of electroneutral cation-chloride cotransporters.
Adriana, Mercado +2 more
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The Na-K-Cl Cotransporter of Secretory Epithelia
Annual Review of Physiology, 2000▪ Abstract The Na-K-Cl cotransporters are a class of ion transport proteins that transport Na, K, and Cl ions into and out of cells in an electrically neutral manner, in most cases with a stoichiometry of 1Na:1K:2Cl. To date, two Na-K-Cl cotransporter isoforms have been identified: NKCC1, which is present in a wide variety of secretory epithelia and ...
M, Haas, B, Forbush
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Asymmetry of Na-K-Cl cotransport in human erythrocytes
American Journal of Physiology-Cell Physiology, 1988The Na-K-Cl cotransport system in human erythrocytes was studied by measuring net influxes and effluxes of Na and K. The influx of K was shown to be stimulated by Na and the influx of Na was stimulated by K, satisfying the fundamental criterion of cotransport.
G R, Kracke, M A, Anatra, P B, Dunham
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Regulation of renal Na-(K)-Cl cotransporters by vasopressin
Pflügers Archiv - European Journal of Physiology, 2017Vasopressin (AVP) induces antidiuresis, thus playing an essential role in body water and electrolyte homeostasis. Its antidiuretic effects are mediated chiefly by V2 vasopressin receptors (V2R) expressed along the distal nephron and collecting duct epithelia.
Sebastian Bachmann, Kerim Mutig
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Effects of okadaic acid and intracellular Cl- on Na(+)-K(+)-Cl- cotransport
American Journal of Physiology-Cell Physiology, 1995The Na(+)-K(+)-Cl- cotransporter of the squid giant axon requires ATP and is inhibited by intracellular Cl- (Cli-) in a concentration-dependent manner ([Cl-]i > or = 200 mM completely inhibits the cotransporter). In the present study we address the question of whether inhibition of cotransport by Cli- is due to a Cl(i-)-induced increase of protein ...
A A, Altamirano +2 more
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