Results 31 to 40 of about 6,975 (268)
WNK Kinase Signaling in Ion Homeostasis and Human Disease [PDF]
, 2017 This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl- cotransporters
Delpire, Eric +5 more
core +3 more sources
K-Cl Cotransport: Properties and Molecular Mechanism
Cellular Physiology and Biochemistry, 2000 K-Cl cotransport (COT), defined first in red blood cells as the Cl-dependent, ouabain-insensitive bidirectional K transport, encoded by at least four KCC (kalium-chloride-cotransport) genes, is now recognized as a functional and structural reality in all cell membranes. As functional system, K-Cl COT is necessary for volume and ionic homeostasis. Since
P K, Lauf, N C, Adragna
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Functional interaction of the K-Cl cotransporter (KCC1) with the Na-K-Cl cotransporter in HEK-293 cells [PDF]
American Journal of Physiology-Cell Physiology, 1999 We have studied the regulation of the K-Cl cotransporter KCC1 and its functional interaction with the Na-K-Cl cotransporter. K-Cl cotransporter activity was substantially activated in HEK-293 cells overexpressing KCC1 (KCC1-HEK) by hypotonic cell swelling, 50 mM external K, and pretreatment with N-ethylmaleimide (NEM). Bumetanide inhibited 86Rb efflux
C M, Gillen, B, Forbush
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Frontiers in Physiology, 2020 The role of Cl– as an intracellular signaling ion has been increasingly recognized in recent years. One of the currently best described roles of Cl– in signaling is the modulation of the With-No-Lysine (K) (WNK) – STE20-Proline Alanine rich Kinase (SPAK)/
Adrián Rafael Murillo-de-Ozores +6 more
doaj +1 more source
Molecules, 2023 Neurological diseases including Alzheimer’s, Huntington’s disease, Parkinson’s disease, Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are conditions that affect not only individuals but societies on a global scale ...
Patricia Lam +3 more
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NKCC1 and KCC2: Structural insights into phospho-regulation
Frontiers in Molecular Neuroscience, 2022 Inhibitory neurotransmission plays a fundamental role in the central nervous system, with about 30–50% of synaptic connections being inhibitory. The action of both inhibitory neurotransmitter, gamma-aminobutyric-acid (GABA) and glycine, mainly relies on ...
Anna-Maria Hartmann +4 more
doaj +1 more source
Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics. [PDF]
, 2017 Individuals with 22q11.2 microdeletion syndrome (22q11.2 DS) show cognitive and behavioral dysfunctions, developmental delays in childhood and risk of developing schizophrenia and autism.
Amin, Hayder +3 more
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Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function
Frontiers in Neurology, 2020 As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl−) flow, which relies on the intracellular chloride concentration ([Cl−]i)
Ru Liu +13 more
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Modeling glial contributions to seizures and epileptogenesis: cation-chloride cotransporters in Drosophila melanogaster. [PDF]
PLoS ONE, 2014 Flies carrying a kcc loss-of-function mutation are more seizure-susceptible than wild-type flies. The kcc gene is the highly conserved Drosophila melanogaster ortholog of K+/Cl- cotransporter genes thought to be expressed in all animal cell types.
Zeid M Rusan +2 more
doaj +1 more source
Research on ionic homeostatic equilibrium may change our view about epilepsy [PDF]
, 2013 Universidade Federal de Sao Joao Del Rei (UFSJ) Departamento de Engenharia de Biossistemas (DEPEB) Laboratorio de Neurociencia Experimental e Computacional Dr Aristides Azevedo Pacheco LeaoUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de ...
Almeida, Antonio Carlos G. de +4 more
core +4 more sources