Results 31 to 40 of about 50 (50)

CIP1 is an activator of the K+–Cl− cotransporter KCC2

Biochemical and Biophysical Research Communications, 2009
In most neurons, efficient setting of the intracellular Cl(-)-concentration requires the coordinated regulation of the Cl(-)-inward transporter NKCC1 and the Cl(-)-outward transporter KCC2. Previously, the cation-chloride cotransporter interacting protein 1 (CIP1) was shown to inactivate NKCC1. Here, we investigated its role for KCC2 activity. After co-
Anna-Maria Hartmann, Meike Wenz, Hans Gerd Nothwang, Eckhard Friauf   +3 more
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Effects of okadaic acid and intracellular Cl- on Na(+)-K(+)-Cl- cotransport

American Journal of Physiology-Cell Physiology, 1995
The Na(+)-K(+)-Cl- cotransporter of the squid giant axon requires ATP and is inhibited by intracellular Cl- (Cli-) in a concentration-dependent manner ([Cl-]i > or = 200 mM completely inhibits the cotransporter). In the present study we address the question of whether inhibition of cotransport by Cli- is due to a Cl(i-)-induced increase of protein ...
G. E. Breitwieser, John M. Russell, A. A. Altamirano   +2 more
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Molecular Physiology of Mammalian K+-CL− Cotransporters

2006
Potassium-chloride (K-Cl) cotransport is a major pathway for the coupled, electroneutral exit of K and Cl from perhaps all mammalian cells. This transport activity is mediated by KCC proteins encoded by four genes in the SLC12 family of electroneutral cation-chloride cotransporters.
Adriana Mercado, David B. Mount, Gerardo Gamba   +2 more
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Role of Na/K/Cl cotransport in astrocytes

Canadian Journal of Physiology and Pharmacology, 1992
The kinetic characterization of the Na/K/Cl cotransport of cultured astrocytes and evidence for its involvement in volume regulation and K+ net uptake during K+ clearance are reviewed. Emphasis is put on experimental evidence for a proposed sodium cycle in astrocytes; this cycle involves a Na+–K+ ATPase that is stimulated by both a high external K ...
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Asymmetry of Na-K-Cl cotransport in human erythrocytes

American Journal of Physiology-Cell Physiology, 1988
The Na-K-Cl cotransport system in human erythrocytes was studied by measuring net influxes and effluxes of Na and K. The influx of K was shown to be stimulated by Na and the influx of Na was stimulated by K, satisfying the fundamental criterion of cotransport.
Philip B. Dunham, M. A. Anatra, G. R. Kracke   +2 more
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Regulation of renal Na-(K)-Cl cotransporters by vasopressin

Pflügers Archiv - European Journal of Physiology, 2017
Vasopressin (AVP) induces antidiuresis, thus playing an essential role in body water and electrolyte homeostasis. Its antidiuretic effects are mediated chiefly by V2 vasopressin receptors (V2R) expressed along the distal nephron and collecting duct epithelia.
Sebastian Bachmann, Kerim Mutig
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Na‐K‐Cl Cotransport in Chloride‐transporting Epithelia^a

Annals of the New York Academy of Sciences, 1985
The elasmobranch rectal gland has served as a useful model to study features of Na-K-Cl cotransport that are common to many chloride-transporting epithelia. These include: (1) dependence on a Na+ gradient created by Na-K-ATPase; (2) high intracellular Cl- concentration; (3) characteristic inhibitor profile including inhibition by loop diuretics and ...
Patricio Silva, Franklin H. Epstein
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K+-Cl- Cotransport in Vertebrate Red Cells

2003
The “pump-leak” model of Tosteson and Hoffman (1960) presented an elegant and simple paradigm for regulation of red blood cell (RBC) cation content and volume. It emphasised the importance of a specific, ouabain-sensitive, Na+/K+ pump, driven by ATP, as the primary active transport process for maintaining high intracellular K+, balancing K+ loss ...
J. Clive Ellory, John S. Gibson
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Regulatory phosphorylation of the secretory Na-K-Cl cotransporter: modulation by cytoplasmic Cl

American Journal of Physiology-Cell Physiology, 1996
The effect of cytoplasmic Cl concentration ([Cl]i) on the activation state ([3H]benzmetanide binding rate) and phosphorylation state (32P incorporation) of the Na-K-Cl cotransporter was evaluated in secretory tubules isolated from the dogfish shark rectal gland.
Christian Lytle, Biff Forbush
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The Role of K+-Cl−-Cotransporter-2 in Neuropathic Pain

Neurochemical Research, 2018
The pain sensory system normally functions under a fine balance between excitation and inhibition. When this balance is perturbed for some reason, it leads to neuropathic pain. There is accumulating evidence that attributes this pain generation to specific dysfunctions of the inhibitory system in the spinal cord.
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