Results 111 to 120 of about 18,493,508 (291)
An Essay on the Philosophy and Psychodynamics of Income Distribution
, 1992 This essay considers certain fundamental aspects of the philosophy and psychodynamics of distribution and how they have entered economic theory. It treats, first, considerations of distribution as a driving force in the economy; second, the forces and ...
Samuels, W. J.
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The Beaman Distribution: A New Descriptive Model for the Size Distribution of Incomes
, 2008 A new two-parameter descriptive model for the size distribution of incomes is presented. The Beaman distribution, originally found to describe the relationship between prices and sales volumes of textiles and related products, is shown to fit closely US ...
Maclachlan, Fiona C., Reith, John E.
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Oversampling Algorithm Based on Improved K-Means and Gaussian Distribution
InformationOversampling is common and effective in resolving the classification problem of imbalanced data. Traditional oversampling methods are prone to generating overlapping or noisy samples.
Wenhao Xie, Xiao Huang
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
LINEAR PREDICTION OF K-RECORD VALUES FROM GENERALIZED PARETO DISTRIBUTION
Reliability: Theory & ApplicationsIn this paper, the upper k-record values arising from a generalized Pareto distribution is considered. After considering the means, variances and covariances of the upper k-record values, the best linear unbiased estimators and best linear invariant ...
Laji Muraleedharan, Manoj Chacko
doaj +1 more source