Results 151 to 160 of about 20,244,257 (338)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Estimation of parameters in the discrete distributions of order k

Binomial distribution of order k , geometric distribution of order k , Poisson distribution of order k , logarithmic series distribution of order k , parametric estimation, method of moments, maximum likelihood,
S. Aki, K. Hirano
core   +1 more source

k-means clustering: Clusters distribution for k = 160 with overlapping technique.

, 2016
k-means clustering: Clusters distribution for k = 160 with overlapping technique.
Hashem Tamimi (3359189), Yaqoub Ashhab (561364), Ahmad Tamimi (3359192)   +2 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Chemical fractions of potassium in arid region calcareous soils: The impact of microclimates and physiographic variability.

PLoS ONE
Factors such as topography, mineralogy, physicochemical properties, and climate can affect the distribution of soil potassium (K) forms. However, often the special effects of physiographic units are neglected.
Morteza Poozesh Shirazi, Sayyed Mahmoud Enjavinezhad, Ali Akbar Moosavi   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Evaluation of Temperature Distribution in Thermal Forming Process of Steel Plate by Oxy-gas Source Line Heating

Journal of Advanced Materials in Engineering, 2017
The aim of the present research is calculation and determination of the temperature distribution in the oxy-gas source line heating process for application in the steel plates.
S. R. Hosseini, M. Barati, E. Maghsoudi
doaj   +2 more sources

Possible signal of an exotic $$I=1$$ I = 1 , $$J=2$$ J = 2 state in the $$B \rightarrow D^{*-}D^+K^+$$ B → D ∗ - D + K + reaction

European Physical Journal C: Particles and Fields
We study the $$B^+ \rightarrow D^{*-}D^+K^+$$ B + → D ∗ - D + K + reaction, showing that a peak in the $$D^+K^+$$ D + K + mass distribution around $$2834 \text { MeV}$$ 2834 MeV reported by LHCb could be associated with a theoretical exotic state with ...
Wen-Tao Lyu, Man-Yu Duan, Chu-Wen Xiao, En Wang, Eulogio Oset   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Beta Type 3 Distribution and Its Multivariate Generalization

, 2015
[[abstract]]The beta type 3 distribution has been obtained from the beta type 1 distribution by means of variable transformation. The beta type 3 distribution which is defined on bounded interval may serve as an alternative to the beta type 1 ...
Sánchez, Luz Estela, Cardeño, Liliam, Nagar, Daya K.   +2 more
core