Results 221 to 230 of about 20,244,257 (338)

Contemporary multicentre analysis of carbapenemases distribution among clinical carbapenem-resistant Enterobacterales in Lebanon. [PDF]

JAC Antimicrob Resist
Tannous J, Saliba R, Mghames A, Tokajian S, Attieh R, Jisr T, Barhoun J, Diab MK, Shakra DA, Mokhbat J, Al Souheil A, Zorkot W, Jaffal F, Salman H, Husni R, Rahban H, Khoury E, Mohsen Z, Abboud E, Youssef M, Karayakoupoglo G, Fawaz I, Houmani M, Abdallah D, Moghnieh R.   +24 more
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Particle sizing in milk by combined differential dynamic microscopy and cryo-FIB-SEM tomography.

Soft Matter
Bradley JJ, Laidlaw FHJ, Pendry T, Li NYD, Boggon AK, Glen T, Martinez VA, Arlt J, Thijssen JHJ, Poon WCK.   +9 more
europepmc   +1 more source

Detection of HPV DNA in Cervical Intraepithelial Neoplasia Using In Situ Hybridization. [PDF]

J Clin Med
Przybylski M, Millert-Kalińska S, Pruski D, de Mezer M, Krzyżaniak M, Jach R, Żurawski J, Kurzawa P.   +7 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Observational constraints from global ice-phase fraction indicate moderate climate sensitivity. [PDF]

Sci Adv
Zhou R, Dou T, Zhou C, Tan I, Chen D, Xu G, Yang Y, Gong X, Ju X, Wang A, Xiao C.   +10 more
europepmc   +1 more source

Computing the Two-Sided Kolmogorov-Smirnov Distribution

We propose an algorithm to compute the cumulative distribution function of the two-sided Kolmogorov-Smirnov test statistic D_n and its complementary distribution in a fast and reliable way.
Pierre L'Ecuyer, Richard Simard
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Experimental investigation and reliability-based optimization of the nut factor in bolted joints considering friction coefficient, surface roughness and material hardness. [PDF]

PLoS One
Tran VT, Nguyen HL.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source