Cytotoxic Activity of α-Aminophosphonic Derivatives Coming from the Tandem Kabachnik–Fields Reaction and Acylation [PDF]
Pharmaceuticals, 2023 Encouraged by the significant cytotoxic activity of simple α-aminophosphonates, a molecular library comprising phosphonoylmethyl- and phosphinoylmethyl-α-aminophosphonates, a tris derivative, and N-acylated species was established.
Petra R. Varga +4 more
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Synthesis of α-Aminophosphonates and Related Derivatives; The Last Decade of the Kabachnik–Fields Reaction [PDF]
Molecules, 2021 The Kabachnik–Fields reaction, comprising the condensation of an amine, oxo compound and a P-reagent (generally a >P(O)H species or trialkyl phosphite), still attracts interest due to the challenging synthetic procedures and the potential biological ...
Petra R. Varga, György Keglevich
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The Last Decade of Optically Active α-Aminophosphonates [PDF]
Molecules, 2023 α-Aminophosphonates and related compounds are important due to their real and potential biological activity. α-Aminophosphonates may be prepared by the Kabachnik–Fields condensation of oxo compounds, amines and dialkyl phosphites, or by the aza-Pudovik ...
Petra R. Varga, György Keglevich
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Microwave-Assisted Kabachnik–Fields Reaction with Amino Alcohols as the Amine Component [PDF]
Molecules, 2019 In this paper, the microwave (MW)-assisted catalyst-free and mostly solvent-free Kabachnik−Fields reaction of amino alcohols, paraformaldehyde, and various >P(O)H reagents (dialkyl phosphites, ethyl phenyl-H-phosphinate, and secondary phosphine ...
Ádám Tajti +4 more
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The Kabachnik–Fields Reaction: Mechanism and Synthetic Use [PDF]
Molecules, 2012 The Kabachnik–Fields (phospha-Mannich) reaction involving the condensation of primary or secondary amines, oxo compounds (aldehydes and ketones) and >P(O)H species, especially dialkyl phosphites, represents a good choice for the synthesis of α ...
György Keglevich, Erika Bálint
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Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions [PDF]
Molecules, 2023 Several bis(α-aminophosphonates) have been conveniently prepared in good yields using a straightforward multicomponent Kabachnik–Fields reaction between ethane 1,2-diamine or propane 1,3-diamine, diethylphosphite and aldehydes under catalyst-free ...
Ichrak Souii +6 more
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Recent Developments in Functional Polymers via the Kabachnik–Fields Reaction: The State of the Art [PDF]
MoleculesRecently, multicomponent reactions (MCRs) have attracted much attention in polymer synthesis. As one of the most well-known MCRs, the Kabachnik–Fields (KF) reaction has been widely used in the development of new functional polymers.
Rui Yuan +3 more
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Microwaves as “Co-Catalysts” or as Substitute for Catalysts in Organophosphorus Chemistry [PDF]
Molecules, 2021 The purpose of this review is to summarize the importance of microwave (MW) irradiation as a kind of catalyst in organophosphorus chemistry. Slow or reluctant reactions, such as the Diels-Alder cycloaddition or an inverse-Wittig type reaction, may be ...
György Keglevich
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Synthesis of Alkyl α-Amino-benzylphosphinates by the Aza-Pudovik Reaction; The Preparation of the Butyl Phenyl-H-phosphinate Starting P-Reagent [PDF]
MoleculesButyl phenyl-H-phosphinate that is not available commercially was prepared from phenyl-H-phosphinic acid by three methods: by alkylating esterification (i), by microwave-assisted direct esterification (ii), and unexpectedly, by thermal esterification ...
Bence Bajusz +7 more
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Preparation of Naphthalene-Based Flame Retardant for High Fire Safety and Smoke Suppression of Epoxy Resin [PDF]
Molecules, 2023 One of the current challenges in the development of flame retardants is the preparation of an environmentally friendly multi-element synergistic flame retardant to improve the flame retardancy, mechanical performance, and thermal performance of ...
Ziqin Huang +6 more
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