Results 61 to 70 of about 2,952 (186)
Introduction: Hypogonadotropic hypogonadism (HH) is a heterogenous disease caused by mutations in several genes. Based on the presence of hyposmia/anosmia it is distinguished into Kallmann syndrome and isolated HH.
Elisa eDella Valle+14 more
doaj +1 more source
Ndr2 participates in the T788/789 phosphorylation of the integrin β1 integrin subunit. Ndr2 deficiency reduces synaptic density, diminishes CA1 LTP, and impairs spatial memory. Activation of integrins restores the plasticity impairment of Ndr2 deficient mice. Ndr2 is involved in integrin‐dependent synapse formation and plasticity in the hippocampus CA1.
Miguel del Ángel+8 more
wiley +1 more source
Pubertal delay can be due to hypogonadotropic hypogonadism (HH), which may occur in association with anosmia or hyposmia and is known as Kallmann syndrome (OMIM #308700).
Lourdes Correa Brito+18 more
doaj +1 more source
Testosterone and men's health: An in‐depth exploration of their relationship
Abstract Testosterone plays a pivotal role in male health throughout the lifespan. Men generally exhibit higher serum testosterone levels than women, influencing critical aspects of male physiology. It drives normal sexual differentiation during fetal development, promotes the acquisition of pubertal traits, and induces the development of secondary ...
Aksam Yassin+9 more
wiley +1 more source
Abstract Background The question of whether patients are more likely to succeed with testicular sperm intracytoplasmic sperm injection (T‐ICSI) after unsuccessful ICSI with ejaculated sperm (Ej‐ICSI) remains unknown. Objective The study aimed to identify potential predictors of successful T‐ICSI in men with idiopathic infertility and oligozoospermia ...
Muhammed Arif Ibis+6 more
wiley +1 more source
Summary Background The diagnosis of monogenic obesity is burdened by frequent variants of uncertain significance (VUS). We describe our real‐life approach of variant reassessment over time and we assess whether inconclusive variants are decreasing in monogenic obesity.
Anita Morandi+12 more
wiley +1 more source
Kallmann Syndrome. Case presentation
Kallmann syndrome is characterized by the association of hypogonadotropic hypogonadism and anosmia. It affects one of every 10 000 and 50 000 women.
Elodia Rivas Alpízar+3 more
doaj +2 more sources
Abstract Background and objective The longitudinal efficacy and clinical utility of Testosterone Therapy (TTh) in ameliorating functional hypogonadism (FH) remain contentious, with long‐term data being scarce. To address this lacuna, a comprehensive long‐term registry study, stratifying patients across a spectrum of hypogonadal etiologies, offers a ...
Michael Zitzmann+4 more
wiley +1 more source
Society for endocrinology guideline for understanding, diagnosing and treating female hypogonadism
Abstract Female hypogonadism (FH) is a relatively common endocrine disorder in women of premenopausal age, but there are significant uncertainties and wide variation in its management. Most current guidelines are monospecialty and only address premature ovarian insufficiency (POI); some allude to management in very brief and general terms, and most ...
Channa N. Jayasena+13 more
wiley +1 more source
Disorders of puberty and neurodevelopment: A shared etiology?
Disorders of puberty result primarily from dysregulation of gonadotropin‐releasing hormone secretion in the hypothalamus. Studies have uncovered associations between pubertal timing and neurodevelopment. This review discusses the overlap between the brain circuitry controlling puberty and behavior, highlights neurodevelopmental conditions with ...
Jordan E. Read+5 more
wiley +1 more source