Results 61 to 70 of about 2,952 (186)

Prevalence of olfactory and other developmental anomalies in patients with central hypogonadotropic hypogonadism

open access: yesFrontiers in Endocrinology, 2013
Introduction: Hypogonadotropic hypogonadism (HH) is a heterogenous disease caused by mutations in several genes. Based on the presence of hyposmia/anosmia it is distinguished into Kallmann syndrome and isolated HH.
Elisa eDella Valle   +14 more
doaj   +1 more source

The Serine/Threonine Kinase NDR2 Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus

open access: yesJournal of Neurochemistry, Volume 169, Issue 6, June 2025.
Ndr2 participates in the T788/789 phosphorylation of the integrin β1 integrin subunit. Ndr2 deficiency reduces synaptic density, diminishes CA1 LTP, and impairs spatial memory. Activation of integrins restores the plasticity impairment of Ndr2 deficient mice. Ndr2 is involved in integrin‐dependent synapse formation and plasticity in the hippocampus CA1.
Miguel del Ángel   +8 more
wiley   +1 more source

Case report: Novel SIN3A loss-of-function variant as causative for hypogonadotropic hypogonadism in Witteveen–Kolk syndrome

open access: yesFrontiers in Genetics
Pubertal delay can be due to hypogonadotropic hypogonadism (HH), which may occur in association with anosmia or hyposmia and is known as Kallmann syndrome (OMIM #308700).
Lourdes Correa Brito   +18 more
doaj   +1 more source

Testosterone and men's health: An in‐depth exploration of their relationship

open access: yesUroPrecision, Volume 3, Issue 1, Page 36-46, March 2025.
Abstract Testosterone plays a pivotal role in male health throughout the lifespan. Men generally exhibit higher serum testosterone levels than women, influencing critical aspects of male physiology. It drives normal sexual differentiation during fetal development, promotes the acquisition of pubertal traits, and induces the development of secondary ...
Aksam Yassin   +9 more
wiley   +1 more source

Testicular sperm retrieval for intracytoplasmic sperm injection: when to consider it after unsuccessful intracytoplasmic sperm injection with ejaculated sperm?

open access: yesAndrology, Volume 13, Issue 2, Page 243-250, February 2025.
Abstract Background The question of whether patients are more likely to succeed with testicular sperm intracytoplasmic sperm injection (T‐ICSI) after unsuccessful ICSI with ejaculated sperm (Ej‐ICSI) remains unknown. Objective The study aimed to identify potential predictors of successful T‐ICSI in men with idiopathic infertility and oligozoospermia ...
Muhammed Arif Ibis   +6 more
wiley   +1 more source

Variant reclassification over time decreases the level of diagnostic uncertainty in monogenic obesity: Experience from two centres

open access: yesPediatric Obesity, Volume 19, Issue 12, December 2024.
Summary Background The diagnosis of monogenic obesity is burdened by frequent variants of uncertain significance (VUS). We describe our real‐life approach of variant reassessment over time and we assess whether inconclusive variants are decreasing in monogenic obesity.
Anita Morandi   +12 more
wiley   +1 more source

Kallmann Syndrome. Case presentation

open access: yesMedisur, 2016
Kallmann syndrome is characterized by the association of hypogonadotropic hypogonadism and anosmia. It affects one of every 10 000 and 50 000 women.
Elodia Rivas Alpízar   +3 more
doaj   +2 more sources

TRACK_9: Testosterone replacement assessment: Classical vs. functional hypogonadism‐knowledge from a 9‐year study

open access: yesAndrology, Volume 12, Issue 8, Page 1675-1696, November 2024.
Abstract Background and objective The longitudinal efficacy and clinical utility of Testosterone Therapy (TTh) in ameliorating functional hypogonadism (FH) remain contentious, with long‐term data being scarce. To address this lacuna, a comprehensive long‐term registry study, stratifying patients across a spectrum of hypogonadal etiologies, offers a ...
Michael Zitzmann   +4 more
wiley   +1 more source

Society for endocrinology guideline for understanding, diagnosing and treating female hypogonadism

open access: yesClinical Endocrinology, Volume 101, Issue 5, Page 409-442, November 2024.
Abstract Female hypogonadism (FH) is a relatively common endocrine disorder in women of premenopausal age, but there are significant uncertainties and wide variation in its management. Most current guidelines are monospecialty and only address premature ovarian insufficiency (POI); some allude to management in very brief and general terms, and most ...
Channa N. Jayasena   +13 more
wiley   +1 more source

Disorders of puberty and neurodevelopment: A shared etiology?

open access: yesAnnals of the New York Academy of Sciences, Volume 1541, Issue 1, Page 83-99, November 2024.
Disorders of puberty result primarily from dysregulation of gonadotropin‐releasing hormone secretion in the hypothalamus. Studies have uncovered associations between pubertal timing and neurodevelopment. This review discusses the overlap between the brain circuitry controlling puberty and behavior, highlights neurodevelopmental conditions with ...
Jordan E. Read   +5 more
wiley   +1 more source

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