ChemMedChem, Volume 21, Issue 17, 14 September 2026.An investigation of the tandem Tudor domain (TTD) domain of UHRF1 identified and extensively characterized the local anesthetic hydroxyprocaine as a strong ligand capable of activating related genes such as p53 and also highlighted a new, potentially druggable intramolecular interaction between TTD and UBL.
Efstratios Tsakalidis +16 more
wiley +1 more source
Solid Phase Peptide Synthesis: Analysis and Identification of Protein Kinase Substrates [PDF]
, 2005 This research study examines the synthesis of tyrosine containing peptides based on the protein paxillin. Paxillin is a proposed substrate of the Focal Adhesion Kinase (FAK) protein tyrosine kinase.
Kroodsma, Derrick
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Phlorizin does not ameliorate kanamycin-induced ototoxicity.
, 2014 Three weeks after dosing, mice treated with kanamycin in DPBS or mice treated with kanamycin plus DMSO (vehicle for phlorizin) had significant ABR threshold shifts at 32 kHz only compared to mice treated with DPBS only ...
Hongzhe Li (26250) +5 more
core +1 more source
Evolution of breast cancer therapeutics: Breast tumour kinase’s role in breast cancer and hope for breast tumour kinase targeted therapy [PDF]
, 2014 This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). © 2014 Baishideng Publishing Group Inc.There have been significant improvements in the detection
Hussain, HA, Harvey, A
core +1 more source
Casein kinase 2 controls synapse organization and stability [PDF]
, 2013 Synapse remodeling is a local and dynamic process, requiring constant modifications of the neuronal network. Post-translational modifications, such as reversible phosphorylation by kinases and phosphatases, play a crucial role in synapse development and ...
Bulat, Victoria
core +1 more source
Structural and functional studies on nucleotide binding to AMP-activated protein kinase [PDF]
, 2010 AMP-activated protein kinase (AMPK) is an enzyme that senses and regulates cellular energy balance thus playing a key role in homeostasis. As such it is a target for treatment of metabolic disorders such as type II diabetes.
Saiu, P.
core
reservedIl genoma umano è costituito principalmente da brevi sequenze di DNA ripetute. A causa di polimorfismo e mutazioni, tali sequenze possono allungarsi diventando anomale oltre una specifica soglia di lunghezza.
BIASIOTTO, MADDALENA
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Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling [PDF]
, 2001 The "metabolic cocktail" comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that insulin is the major component mediating this protection and acts via Akt prosurvival signaling ...
Sack, M.N. +3 more
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Functional studies of serine/threonine protein kinase signalling in Mycobacterium tuberculosis. [PDF]
, 2006 Fork-head associated (FHA) domains function in the assembly of signalling complexes through specific interactions with phospho-threonine motifs. FHA domains are found in eukaryotes, and intriguingly in a subset of bacterial species including Mycobacteria
Patel, D.P.
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Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer [PDF]
, 2007 Tumor angiogenesis is a process that requires migration, proliferation, and differentiation of endothelial cells. We hypothesized that decrease in pancreatic tumor growth due to inhibition of src activity is associated with the inability of src kinase to
Ischenko, Ivan
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