Results 51 to 60 of about 751,968 (244)

Extrapolating empirical long-term survival data: the impact of updated follow-up data and parametric extrapolation methods on survival estimates in multiple myeloma

BMC Medical Research Methodology, 2023
Background In economic evaluations, survival is often extrapolated to smooth out the Kaplan-Meier estimate and because the available data (e.g., from randomized controlled trials) are often right censored.
LJ Bakker, FW Thielen, WK Redekop, CA Uyl-de Groot, HM Blommestein   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Kaplan-Meier curves.

, 2019
Kaplan-Meier curves for overall survival of all datasets.
Jean-Pierre Muratet (6791678), Henry C. Woodruff (6791684), Janna E. van Timmeren (4380730), Arthur Jochems (457754), Ursula Nestle (4244182), Ralph T. H. Leijenaar (805757), Fabrice Denis (6791681), Wouter van Elmpt (810401), Sara Carvalho (169189), Tanja Schimek-Jasch (4798836), Cary Oberije (810402), Philippe Lambin (19883), Esther G. C. Troost (815660), Dirk de Ruysscher (4513534)   +13 more
core   +1 more source

Kaplan-Meier analysis of overall survival.

, 2021
Kaplan-Meier analysis of overall survival.
Kanokphorn Thonglert (11473288), Chonlakiet Khorprasert (11473285), Napapat Amornwichet (677960), Petch Alisanant (11473291)   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Kaplan-Meier Survival Estimates.

, 2016
Kaplan-Meier Survival Estimates.
Folefac D. Atem (3597125), Shannon Anjelica Allport (3597122), Fonkem Ekokobe (3597119), Ngum Kikah (3597116), Nessim Abu Saif (3597128)   +4 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Comparison between Kaplan-Meier and Weighted Kaplan-Meier Methods of Five-Year Survival Estimation of Patients with Gastric Cancer

Acta Medica Iranica, 2014
The 5-year survival rate is a good prognostic indicator for patients with Gastric cancer that is usually estimated based on Kaplan-Meier. In situations where censored observations are too many, this method produces biased estimations. This study aimed to
Ali Zare, Mahmood Mahmoodi, Kazem Mohammad, Hojjat Zeraati, Mostafa Hosseini, Kourosh Holakouie Naieni   +5 more
doaj  

Kaplan-Meier-Curves based on control tissue MI.

, 2016
Kaplan-Meier-Curves for patients with a MI concentration in the control tissue at baseline > 4.696 (OS 270 days, color: red) compared to patients with a MI concentration < 4.696 (median overall survival (OS 206 days, color: brown).The figure shows an ...
Ulrich Pilatus (294953), Oliver Bähr (387031), Eike Steidl (3607406), Friedhelm Zanella (3607409), Michael W. Ronellenfitsch (553781), Elke Hattingen (294963), Joachim P. Steinbach (539474)   +6 more
core   +1 more source