Results 51 to 60 of about 737,568 (236)

A Combined Score of Circulating miRNAs Allows Outcome Prediction in Critically Ill Patients [PDF]

, 2019
Background and aims: Identification of patients with increased risk of mortality represents an important prerequisite for an adapted adequate and individualized treatment of critically ill patients.
Benz, Fabian, Koch, Alexander, Loosen, Sven H., Luedde, Mark, Luedde, Tom, Roderburg, Christoph, Spehlmann, Martina, Tacke, Frank, Trautwein, Christian, Vucur, Mihael, Wree, Alexander   +10 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Turnbull versus Kaplan-Meier estimators of cure rate estimation using interval censored data [PDF]

, 2012
This study deals with the analysis of the cure rate estimation based on the Bounded Cumulative Hazard (BCH) model using interval censored data, given that the exact distribution of the data set is unknown.
Abu Bakar, Mohd Rizam, Aljawadi, Bader Ahmad I., Ibrahim, Noor Akma   +2 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Nonparametric survival analysis of epidemic data

, 2011
This paper develops nonparametric methods for the survival analysis of epidemic data based on contact intervals. The contact interval from person i to person j is the time between the onset of infectiousness in i and infectious contact from i to j, where
Aalen, Aalen, Altshuler, Becker, Becker, Carcione, Cauchemez, Cox, Dempster, Donnelly, Ferguson, Ferguson, Fine, France, Fraser, Kalbfleisch, Kaplan, Kenah, Kenah, Lee, Lipsitch, McBryde, Mills, Morgan, Müller, Nelson, Rampey, Rhodes, Roberts, Sinha, Sugimoto, Svensson, Van der Vaart, Wallinga, Wallinga, Watts, Wegman, White, Yang   +38 more
core   +1 more source

Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria [PDF]

, 2018
Background: The urinary proteomic classifier CKD273 has shown promise for prediction of progressive diabetic nephropathy (DN). Whether it is also a determinant of mortality and cardiovascular disease in patients with microalbuminuria (MA) is unknown.
Currie, Gemma E., Delles, Christian, Flores Guerrero, Jose-Luis, Jacobsen, Peter K., Lindhardt, Morten, Mary, Sheon, Mischak, Harald, Mullen, William, Parving, Hans-Henrik, Reinhard, Henrik, Rossing, Peter, von Scholten, Bernt Johan   +11 more
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Estimador de Kaplan-Meier na avaliação do tempo de conclusão do Profmat/UFSJ

REMAT, 2019
A presença de dados incompletos ou censuras no conjunto de dados requer técnicas estatísticas especializadas para acomodar a informação contida nessas observações, tais como a Análise de Sobrevivência.
Roberta Cristina Ferreira Arvelos, Carla Regina Guimarães Brighenti   +1 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Inferences for current chronic graft-versus-host-disease free and relapse free survival

BMC Medical Research Methodology, 2022
This paper provides the methodologies of a new summary curve that measures the dynamic outcome following allogenic hematopoietic cell transplantation.
Xu Zhang, Scott R. Solomon, Connie Sizemore   +2 more
doaj   +1 more source