Results 201 to 210 of about 156,286 (266)

Lactylation-driven gene signatures define breast cancer prognosis: a predictive model and insights into immune microenvironment dynamics. [PDF]

Eur J Med Res
Li C, Hu C, Liu X, Li M.
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Predicting skin melanoma progression via LAG-3, TIGIT and HAVCR2. [PDF]

Funct Integr Genomics
Vryza P, Georgakopoulos-Soares I, Zaravinos A.   +2 more
europepmc   +1 more source

The Distribution of the Bivariate Kaplan-Meier Estimate

, 1988
Ronald C. Pruitt
openalex   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Cancer survival in Lower Silesia: insights from a national oncology network pilot in Poland. [PDF]

Front Oncol
Władysiuk M, Zawadzki P, Prędkiewicz P, Plisko R, Błaszczyk D, Matkowski R, Maciejczyk A, Cybulska-Stopa B.   +7 more
europepmc   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Development of a post-treatment prognostic model for hepatocellular carcinoma based on nutritional, immune, and inflammatory scoring systems and REDCap-enabled follow-up. [PDF]

Front Oncol
Liu X, Wei C, Jiang M, Huang F, Wu H, Liao X, Huang Z, Liu Z.   +7 more
europepmc   +1 more source

Kaplan-Meier estimate of hypoglycemia-free survival probability based on neonatal sepsis among neonates admitted to HUCSH, 2025.

Sintayehu Amare Tessema (22250614), Desalegn Dawit Assele (11302533), Henok Bekele Kebede (22250617), Yitayew Ewnetu Mohammed (20995640)   +3 more
openalex   +1 more source

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source