Results 231 to 240 of about 2,137,840 (268)

RAB37 Exerts a Context-Dependent Role in Cutaneous Melanoma Progression by Promoting Tumor Cell Proliferation and Being Associated with Favorable Immune Characteristics. [PDF]

Cancer Manag Res
Zhu M, Wang Y, Zhang Y, Zhu L, Guo W.
europepmc   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Association of type 2 diabetes mellitus with postoperative outcomes following single-level endoscopic lumbar interbody fusion through a posterior approach: A global propensity score-matched cohort study. [PDF]

PLoS One
Dang PG, Chen YP, Nguyen TT, Nguyen DH, Kuo YJ.   +4 more
europepmc   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Outcomes of loncastuximab tesirine in heavily pretreated patients with diffuse large B-cell lymphoma, including the post-CAR T-cell therapy setting: A meta-analysis. [PDF]

Cancer
Gibran-Nunes F, Pêcego H, Santos J, Nunes Y, Freitas B, Rena J, Fogale M, Ferreira A, Seiwald M, Xue E, Cortez A, Fonseca A, Xavier E, Serpa M, Tucunduva L, Novis Y.   +15 more
europepmc   +1 more source

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

Advanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao, Jian Zhang, Qi Qian, Min Jiang, Yu Liu, Yan Geng, Nan Cui, Qi Guo, Jie Guo   +8 more
wiley   +1 more source

Predicting median survival times from early data in immunotherapy trials using exponential-decay modeling. [PDF]

J Natl Cancer Inst
Opperman T, Patel R, Chiong JD, Stewart DJ, Nasser A.   +4 more
europepmc   +1 more source

Single-fraction stereotactic radiotherapy for lung malignancies: preliminary results of a mono-institutional experience. [PDF]

Front Oncol
Cuccia F, Mortellaro G, Campione M, Figlia V, Spera A, Cespuglio D, D'Alessandro S, Napoli C, Azzarello F, Verderame F, Failla G, Blasi L, Carruba G, Ferrera G.   +13 more
europepmc   +1 more source

Imaging-Guided Versus Conventional Ventricular Tachycardia Ablation in Ischemic Cardiomyopathy: A Systematic Review and Meta-Analysis. [PDF]

J Arrhythm
Ahmed S, Sawalha K, Sharief M, Ammar A.
europepmc   +1 more source