Results 41 to 50 of about 511,435 (213)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A Berry-Esseen Type Bound in Kernel Density Estimation for Negatively Associated Censored Data

Journal of Applied Mathematics, 2013
We discuss the kernel estimation of a density function based on censored data when the survival and the censoring times form the stationary negatively associated (NA) sequences.
Qunying Wu, Pingyan Chen
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Kaplan-Meier-curve for overall HrCLM-free proportion.

, 2018
Kaplan-Meier-curve for overall HrCLM-free proportion.
Angela Schuster (339903), Hannah Lesshafft (339904), Felix Reichert (2580943), Daniel Pilger (270591), Silas Guedes de Oliveira (2580940), Ralf Ignatius (158782), Hermann Feldmeier (237850)   +6 more
core   +1 more source

Kaplan–Meier survival curves.

, 2023
(A)Kaplan–Meier survival curves of OS stratified by total LNs. (B)Kaplan–Meier survival curves of OS stratified by PLNs. (C)Kaplan–Meier survival curves of OS stratified by LNR. (D)Kaplan–Meier survival curves of DSS stratified by total LNs.
Yanlin Li (309835), Lei Cai (165530), Jian Wen (286688), Xin Ren (1999087), Xiaodan Liu (849235), Fangjian Shang (8361837), Yujia Sun (200351), Xiaodan Zhai (10904676)   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Examining Selected Theoretical Distributions of Life Expectancy to Analyse Customer Loyalty Durability. The Case of a European Retail Bank

Acta Universitatis Lodziensis. Folia Oeconomica, 2020
One of the key elements related to calculating Customer Lifetime Value is to estimate the duration of a client’s relationship with a bank in the future. This can be done using survival analysis.
Dominik Kubacki, Robert Kubacki
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Simulation Properties of Malani\u27s Modified Kaplan-Meier Estimator

, 1994
This paper describes the properties of Malani\u27s Modified Kaplan-Meier estimator (Malani (1992)) when sample sizes are moderate, censoring is both noninformative and informative, the level of censoring is moderate to heavy, and when marker values are ...
Percell, Sandra R., Malani, Hina M.
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source