Results 91 to 100 of about 913,429 (284)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

A decision-theoretic method for analyzing crossing survival curves in healthcare

open access: yesHealthcare Analytics
The problem of crossing Kaplan–Meier curves has not been solved in the medical research literature to date. This paper integrates survival curve comparisons into decision theory, providing a theoretical framework and a solution to the problem of crossing
Elie Appelbaum   +3 more
doaj   +1 more source

The Kaplan Meier Estimate in Survival Analysis

open access: yes, 2017
Kaplan-Meier is a statistical method used in the analysis of time to event data. Time to event means the time from entry into a study until a particular event, for example onset of illness. This method is very useful in survival analysis as it is used by
I. Etikan   +2 more
semanticscholar   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Survival Analysis and its Associated Factors of Beta Thalassemia Major in Hamadan Province

open access: yesIranian Journal of Medical Sciences, 2015
Background: There currently is a lack of knowledge about the long-term survival of patients with beta thalassemia (BT), particularly in regions with low incidence of the disease.
Reza Zamani   +2 more
doaj  

Association of Dose and Frequency on the Survival of Patients on Maintenance of Hemodialysis in China: A Kaplan-Meier and Cox-Proportional Hazard Model Analysis

open access: yesMedical Science Monitor, 2018
Background Dialysis frequency and dose are controversial prognostic factors of hemodialysis morbidity and mortality. The aim of this study was to find out the effect of frequency and dosage of dialysis on mortality and survival in a group of Chinese ...
Yan Sun   +5 more
semanticscholar   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

An evaluation on diagnosis and management patterns of patients with oral squamous cell carcinoma referred to the Cancer Institute of Tehran Medical University during 2010-2021

open access: yesJournal of Craniomaxillofacial Research, 2023
Background: Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity with multiple complications associated with the disease and its treatments and a high mortality rate.
Ata Garajei, Sarah Pishva, Azadeh Emami
doaj  

Survival and dispersal of a defined cohort of Irish cattle

open access: yesIrish Veterinary Journal, 2009
An understanding of livestock movement is critical to effective disease prevention, control and prediction. However, livestock movement in Ireland has not yet been quantified. This study has sought to define the survival and dispersal of a defined cohort
Ashe S   +5 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

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