Advanced Science, EarlyView.A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun +23 more
wiley +1 more source
Survival Outcomes in EGFR-Mutant Non-Small Cell Lung Cancer With Brain Metastases: Kaplan-Meier and Cox Regression Analyses Across Treatment Stages. [PDF]
Clin Respir JQi H, Qiao Q, Sun X, Xing L.
europepmc +1 more source
Mechanisms of action and clinical development of elotuzumab [PDF]
, 2017 Colonna, Marco, Ritchie, David
core +2 more sources
Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
Interval-specific censoring set adjusted Kaplan-Meier estimator. [PDF]
J Appl StatWu Y, Kolassa J.
europepmc +1 more source
Advanced Science, EarlyView.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
Pulsed field ablation vs high-power short duration/very high-power short duration pulmonary vein isolation-Systematic review and meta-analysis with Kaplan-Meier reconstructed individual patient data. [PDF]
Heart Rhythm O2Pranata R +5 more
europepmc +1 more source
Survival analysis (Kaplan-Meier curves): a method to predict the future. [PDF]
Arq Bras Oftalmol, 2020 Lira RPC, Antunes-Foschini R, Rocha EM.
europepmc +1 more source
RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis
Advanced Science, EarlyView.Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao +28 more
wiley +1 more source
Long-term survival and risk factors in esophageal squamous cell carcinoma: A Kaplan-Meier and cox regression study. [PDF]
World J Gastrointest SurgRen ZT, Kang M, Zhu LY, Li P.
europepmc +1 more source