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Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li +13 more
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A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo +8 more
wiley +1 more source
Wasserstein-Kaplan-Meier Survival Regression
Yidong Zhou, Hans-Georg Müller
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Journal of the American Statistical Association, 2004
Miller has studied the asymptotic efficiency of the nonparametric, Kaplan–Meier survival estimator relative to parametric estimates based on the exponential and Weibull distributions. He concluded that in certain cases, the asymptotic efficiency is low and recommended that analysts give more consideration to parametric estimators, particularly for ...
Hui Xie
exaly +4 more sources
Miller has studied the asymptotic efficiency of the nonparametric, Kaplan–Meier survival estimator relative to parametric estimates based on the exponential and Weibull distributions. He concluded that in certain cases, the asymptotic efficiency is low and recommended that analysts give more consideration to parametric estimators, particularly for ...
Hui Xie
exaly +4 more sources
Expert Kaplan–Meier estimation [PDF]
The setting of a right-censored random sample subject to contamination is considered. In various fields, expert information is often available and used to overcome the contamination. This paper integrates expert knowledge into the product-limit estimator in two different ways with distinct interpretations.
Martin Bladt, Christian Furrer
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Biometrics, 1983
The asymptotic efficiency of the Kaplan-Meier product-limit estimator, relative to the maximum likelihood estimator of a parametric survival function, is examined under a random-censoring model.
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The asymptotic efficiency of the Kaplan-Meier product-limit estimator, relative to the maximum likelihood estimator of a parametric survival function, is examined under a random-censoring model.
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Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2005
Kaplan-Meier analysis is largely used in nephrology to estimate a population survival curve from a sample. If patients are followed-up until death, the survival curve can be estimated simply by computing the fraction survival at each time point. Kaplan-Meier analysis allows the estimation of survival over time, even when patients drop out or are ...
G, Tripepi, F, Catalano
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Kaplan-Meier analysis is largely used in nephrology to estimate a population survival curve from a sample. If patients are followed-up until death, the survival curve can be estimated simply by computing the fraction survival at each time point. Kaplan-Meier analysis allows the estimation of survival over time, even when patients drop out or are ...
G, Tripepi, F, Catalano
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2003
Publisher Summary The Kaplan–Meier (K–M) integrals are analogs of empirical integrals when the data are subject to right censoring. They may be viewed as basic statistics to which more complicated quantities may be traced back through linearization.
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Publisher Summary The Kaplan–Meier (K–M) integrals are analogs of empirical integrals when the data are subject to right censoring. They may be viewed as basic statistics to which more complicated quantities may be traced back through linearization.
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Understanding Kaplan-Meier and Survival Statistics
The International Journal of Prosthodontics, 2013This paper aims to explore the mathematics of Kaplan-Meier and survival statistics, explain how the mathematics are relevant for prosthodontic treatment planning, and provide advice for future presentation of such data.The mathematics of the Kaplan-Meier and related survival statistic formulas were explored with hypothetical data consisting of 100 ...
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