Results 251 to 260 of about 877,857 (301)

No difference in overall survival for primary cutaneous Merkel cell carcinoma after Mohs micrographic surgery and wide local excision: A multicenter cohort analysis

JAAD International
Ajay N. Sharma, MD, MBA, Addison M. Demer, MD   +1 more
doaj   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

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The Price of Kaplan–Meier

Journal of the American Statistical Association, 2004
Miller has studied the asymptotic efficiency of the nonparametric, Kaplan–Meier survival estimator relative to parametric estimates based on the exponential and Weibull distributions. He concluded that in certain cases, the asymptotic efficiency is low and recommended that analysts give more consideration to parametric estimators, particularly for ...
Hui Xie, Rick Chappell, Paul Meier
exaly   +4 more sources

Kaplan–Meier Analysis

, 2021
Time to filtration surgery. All eyes at each time point. Success 95.2% Kaplan-Meier survival curve.
Ejaz Ansari (4984259)
openaire   +2 more sources

Kaplan-Meier survival analysis.

, 2022
a. Kaplan-Meier survival analysis of the “any time before” analysis. b. Kaplan-Meier survival analysis of the “within 72h” analysis.
Masamitsu Sanui (3452669), Junji Shiotsuka (4277068), Shigehiko Uchino (2305), Alan Kawarai Lefor (6593720), Tomoyuki Masuyama (12380784), Yusuke Sasabuchi (5052107)   +5 more
openaire   +2 more sources

What Price Kaplan-Meier?

Biometrics, 1983
The asymptotic efficiency of the Kaplan-Meier product-limit estimator, relative to the maximum likelihood estimator of a parametric survival function, is examined under a random-censoring model.
openaire   +2 more sources

Understanding Kaplan-Meier and Survival Statistics

The International Journal of Prosthodontics, 2013
This paper aims to explore the mathematics of Kaplan-Meier and survival statistics, explain how the mathematics are relevant for prosthodontic treatment planning, and provide advice for future presentation of such data.The mathematics of the Kaplan-Meier and related survival statistic formulas were explored with hypothetical data consisting of 100 ...
openaire   +4 more sources