Results 41 to 50 of about 156,165 (266)

Kaplan-Meier Estimate on the Plane

The Annals of Statistics, 1988
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Survival Analysis and its Associated Factors of Beta Thalassemia Major in Hamadan Province

Iranian Journal of Medical Sciences, 2015
Background: There currently is a lack of knowledge about the long-term survival of patients with beta thalassemia (BT), particularly in regions with low incidence of the disease.
Reza Zamani, Salman Khazaei, Shahab Rezaeian   +2 more
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Association between homocysteine levels and hyperlipidemia prevalence as well as all-cause mortality of hyperlipidemia patients in the US population: results from NHANES database

Frontiers in Cardiovascular Medicine
ObjectiveSeveral studies have investigated the correlation between blood lipids and homocysteine, but no clear conclusions have been defined yet. Therefore, we utilized data from National Health and Nutrition Examination Survey (NHANES) to explore the ...
Jia Wei, Qiang Yang, Xiaofang Wang, Xin He, Wenjing Zhu, Lin Lin, Chang Liu, Canzhan Zhu, Mingjuan Zhang   +8 more
doaj   +1 more source

Association of Socioeconomic Disparities With Nasopharyngeal Carcinoma Survival in an Endemic Area, China

Cancer Control, 2023
Objectives This retrospective cohort study investigated the association of socioeconomic status with survival outcomes among patients with nasopharyngeal carcinoma in an endemic area of China. Methods The primary endpoint was overall survival.
Dong-Fang Meng MD, PhD, Hai-Bo Zhang MD, PhD, Guo-Ying Liu MD, PhD, Li-Xia Peng PhD, Qi Yang MD, PhD, Zi-Hao Liu MD, Yaru Tian MD, PhD, Ji Ma MD, Lei Fu MD, PhD   +8 more
doaj   +1 more source

Collecting duct carcinoma of the kidney: Clinicopathological profile and outcomes

Urological Science, 2023
Purpose: Collecting duct carcinoma of the kidney (CDC) is an aggressive subtype of renal cell carcinoma with a dismal prognosis. The available knowledge concerning optimal management is still unclear. We report the largest single-institutional experience
Abhilash Cheriyan, Rajiv Paul Mukha, Shailaja Balakumar, Nirmal Thampi John, Santosh Kumar   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effective TME-related signature to predict prognosis of patients with head and neck squamous cell carcinoma

Frontiers in Molecular Biosciences, 2023
Introduction: The tumor microenvironment (TME) is crucial for the development of head and neck squamous cell carcinoma (HNSCC). However, the correlation of the characteristics of the TME and the prognosis of patients with HNSCC remains less known.Methods:
Lingfei Wan, Lingfei Wan, Yuanshuai Li, Wenting Pan, Wenting Pan, Yuting Yong, Yuting Yong, Chao Yang, Chen Li, Xingxing Zhao, Xingxing Zhao, Ruihong Li, Wen Yue, Wen Yue, Xinlong Yan   +14 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source