Results 51 to 60 of about 218,311 (307)

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, EarlyView.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

Sarcoma de Kaposi en orofaringe en paciente postrasplante renal y manejo con inhibidor de señal de coestimulación e inhibidor de mTOR

Revista Colombiana de Nefrología, 2022
Introducción: el sarcoma de Kaposi en pacientes de postrasplante renal es poco frecuente y está asociado usualmente a infección por herpes 8 y a dosis altas de inmunosupresión. Objetivo: descripción reporte de caso de Sarcoma de Kaposi en orofaringe en
Rodolfo Eduardo Torres-Serrano, Jairo Camilo Montero Cetina, Edwar Ferney Ortiz-Henao, Gloria Constanza Pastrana-Mejía, Larry Salamanca-Rodríguez   +4 more
doaj   +1 more source

Excellent clinical outcomes and retention in care for adults with HIV-associated Kaposi sarcoma treated with systemic chemotherapy and integrated antiretroviral therapy in rural Malawi

Journal of the International AIDS Society, 2015
HIV‐associated Kaposi sarcoma (HIV‐KS) is the most common cancer in Malawi. In 2008, the non‐governmental organization, Partners In Health, and the Ministry of Health established the Neno Kaposi Sarcoma Clinic (NKSC) to treat HIV‐KS in rural Neno ...
M. Herce, Noel Kalanga, E. Wroe, James W. Keck, F. Chingoli, Listern Tengatenga, S. Gopal, Atupere Phiri, Bright G D Mailosi, Junior Bazile, J. Beste, S. Elmore, Jonathan T Crocker, J. Rigodon   +13 more
semanticscholar   +1 more source

Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future [PDF]

, 2015
Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy.
CIRONE, Mara, FAGGIONI, Alberto, FARINA, Antonella, GONNELLA, ROBERTA, GRANATO, Marisa, SANTARELLI, Roberta, TRIVEDI, PANKAJ   +6 more
core   +4 more sources

Identification of ferroptosis‐related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Green part represents the bioinformatics analysis approach. Yellow part represents the ideas of animal experiment. Abstract Background Chronic obstructive pulmonary disease (COPD) is a type of chronic respiratory disease.
Xuejing Luan, Jinghui Xie, Lu Zhang, Xiao Ma, Lichangtian Jiao, Jie Zhu   +5 more
wiley   +1 more source

Kaposi sarcoma of th e penis in anHIV-negative patient

Einstein (São Paulo)
Kaposi sarcoma is an angioproliferative disorder that ranges from a single indolent skin lesion to respiratory and gastrointestinal/visceral involvement. Kaposi sarcoma is rare in non-immunosuppressed patients.
José Francisco Aguilar Guevara, Seila Lacarra Fernández, Oliver Rojas Claros, Pedro Giral Villalta, José Luis Cebrián Lostal, Miguel Angel Resano Abarzuza   +5 more
doaj   +1 more source

The zebrafish xenograft platform-A novel tool for modeling KSHV-associated diseases [PDF]

, 2019
Kaposi\u27s sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes.
Berman, Jason N, Coombs, Andrew J, Dellaire, Graham, Druley, Todd E, Ha, Michael N, McCormick, Craig, Melong, Nicole, O\u27Leary, David, Pringle, Eric S, Robinson, Carolyn-Ann, Veinotte, Chansey, Wertman, Jaime, Young, Andrew L   +12 more
core   +2 more sources

Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening

International Journal of Cancer, EarlyView.
Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar   +4 more
wiley   +1 more source

A case of disseminated angiosarcoma-like Kaposi sarcoma presenting with unusual vesiculobullous lesions

SAGE Open Medical Case Reports
Angiosarcoma-like Kaposi sarcoma represents a recently delineated rare histomorphologic variant of Kaposi sarcoma that can be difficult to distinguish from other vasoproliferative lesions. Conventional lesions of Kaposi sarcoma encompass patches, plaques,
Jasmine Gill, Oluwatosin Odeshi, Muhammad N Mahmood, Parbeer Grewal   +3 more
doaj   +1 more source

Penile Kaposi sarcoma: A case of complete resolution with highly active antiretroviral therapy alone [PDF]

, 2011
Kaposi sarcoma remains an important cause of morbidity in HIV-infected patients. Regardless of the recent pharmacological progress, treatment of this malignancy is still disappointing.
Alves, R., Caetano, M., Pinto-Almeida, T., Rosmaninho, A., Sanches, M., Selores, M., Torres, T.   +6 more
core   +1 more source