Results 31 to 40 of about 359,584 (246)

Development of an Automatic Functional Movement Screening System with Inertial Measurement Unit Sensors

Applied Sciences, 2020
Background: In this study, an automatic scoring system for the functional movement screen (FMS) was developed. Methods: Thirty healthy adults fitted with full-body inertial measurement unit sensors completed six FMS exercises.
Wen-Lan Wu, Meng-Hua Lee, Hsiu-Tao Hsu, Wen-Hsien Ho, Jing-Min Liang   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

APC24-7, a covalent combination of boronic acid and chelator moieties, restores β-lactam efficiency against metallo-β-lactamase-producers

mSphere
β-Lactam/β-lactamase inhibitor combinations have significantly improved treatment outcomes for infections caused by serine β-lactamase (SBL)-producing pathogens.
Rebekka Rolfsnes Hovd, Åsmund Kaupang, Pål Rongved, Geir Kildahl-Andersen, Knut Tormodssønn Hylland, Ragnar Hovland, Ole Andreas Løchen Økstad, Hanne Cecilie Winther-Larsen, Christopher Frøhlich   +8 more
doaj   +1 more source

Clinical, behavioral and antinociceptive effects of crotalphine in horses

Ciência Rural, 2015
: Crotalphine is a novel analgesic peptide that acts on kappa opioid and delta receptors, causing powerful analgesia in rats submitted to inflammatory, neuropathic or oncologic models of pain. This study evaluated clinical, behavioral and antinociceptive
Erica Cristina Bueno do Prado Guirro, João Henrique Perotta, Márcio de Paula, Yara Cury, Carlos Augusto Araújo Valadão   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Clinical profile of Saudi patients with multiple myeloma

Journal of Nature and Science of Medicine, 2019
Background: Multiple myeloma (MM) is a neoplasm of plasma cells. Ethnic variations among the clinical features of MM have been reported. Objectives: This study was performed to assess the clinical features of Saudi MM patients. Patients and Methods: Data
Alanoud Abdulaziz Alhuqayl, Zahid Shakoor, Adel Almogren, Rim Sghiri, Rana Hasanato, Rawan Abdulaziz Albadia   +5 more
doaj   +1 more source

Kappa: Makhluk Mitologis Penjaga Sungai dalam Cerita Rakyat Jepang

Jentera: Jurnal Kajian Sastra, 2020
This article discusses one of the Japanese mythological creatures in the youkai category, the kappa which is believed to be river guardians. Data is taken from the anthology of Japanese folklore Mangga Nippon Mukashi Banashi 101 edited by Sayumi Kawauchi.
Ida Ayu Laksmita Sari
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source