Results 81 to 90 of about 359,584 (246)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

P33 EFFECTIVENESS AND SAFETY OF BELANTAMAB MAFODOTIN IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA IN REAL-LIFE SETTING: THE ALFA STUDY

HemaSphere, 2023
M. Roussel, N. Texier, R. Germain, S. Sapra, P. Paka, N. Kerbouche, X. Colin, X. Leleu   +7 more
doaj   +1 more source

Site Component—k₀ and Its Correlation to V_S30 and the Site Fundamental Frequencies for Stations Installed in N. Macedonia

Geotechnics
This study focuses on determining the high-frequency decay parameter kappa (k) and its site component (k0) for sixteen accelerometric stations installed in suitable locations in North Macedonia.
Marina Poposka, Davor Stanko, Dragi Dojchinovski   +2 more
doaj   +1 more source

Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore

Advanced Functional Materials, EarlyView.
To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul, Archith Rayabharam, Lisa Almonte, Eveline Rigo, Joshy Joseph, Ashutosh Kumar, Zhuxin Dong, Narayana Aluru, Gregory Timp   +8 more
wiley   +1 more source

Shear-Wave Velocity Model from Site Amplification Using Microtremors on Jeju Island

Applied Sciences
This study examines shear-wave velocity structures in the Jeju region utilizing horizontal-to-vertical spectral ratios (HVSRs) of environmental noise, focusing on identifying significant low-velocity layers (LVLs).
Junkyoung Kim, Dongkeuk Park, Gitae Nam, Haiyoung Jung   +3 more
doaj   +1 more source

Local Thermal Conductivity Patterning in Rotating Lattice Crystals of Anisotropic Sb2S3

Advanced Functional Materials, EarlyView.
Microscale control of thermal conductivity in Sb2S3 is demonstrated via laser‐induced rotating lattice crystals. Thermal conductivity imaging reveals marked thermal transport anisotropy, with the c axis featuring amorphous‐like transport, whereas in‐plane directions (a, b) exhibit 3.5x and 1.7x larger thermal conductivity.
Eleonora Isotta, Rosemary Wynnychenko, Binayak Mukherjee, Jack Kaman, Hrushikesh Sahasrabuddhe, Jiongzhi Zheng, Anubhav Jain, Geoffroy Hautier, Alexandra Zevalkink, Evan Musterman, Volkmar Dierolf, Himanshu Jain, G. Jeffrey Snyder, Oluwaseyi Balogun   +13 more
wiley   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Evaluasi Algoritma Machine Learning untuk Klasifikasi dan Prediksi Penggunaan Lahan

Majalah Geografi Indonesia
Abstrak. Pemantauan, perencanaan, dan pengelolaan sumberdaya lahan membutuhkan data penggunaan lahan yang akurat. Banyak penelitian telah dilakukan mengenai klasifikasi dan prediksi penggunaan lahan. Namun, penelitian terkait penentuan metode klasifikasi
Fajar Nugraha, Dwi Putro Tejo Baskoro, Suria Darma Tarigan   +2 more
doaj   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

A MACHINE LEARNING FRAMEWORK FOR SUICIDAL THOUGHTS PREDICTION USING LOGISTIC REGRESSION AND SMOTE ALGORITHM

Barekeng
Suicide, a global health challenge identified in Goal 3 of the global agenda for enhancing worldwide well-being, demands urgent attention. This study focused on predicting suicidal thoughts using machine learning, leveraging the 2021 National Women's ...
Sarni Maniar Berliana, Omas Bulan Samosir, Rafidah Abd Karim, Victoria Pena Valenzuela, Krismanti Tri Wahyuni, Andi Alfian   +5 more
doaj   +1 more source