Results 181 to 190 of about 302,078 (276)

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Kappa free light chains in cerebrospinal fluid to detect inflammation - results from a multicentric prospective real-world study. [PDF]

Front Immunol
Süße M, Hannich MJ, Lottermoser F, Gross S, Budde K, Crnkovic-Mertens I, Thiaucourt M, Roser M, Konen FF, Skripuletz T, Suliman R, Mirtschink P, Bock H, Reuner K, Poitz D, Ziemssen T, Tumani H, Lewerenz J, Khalil M, Harrer A, Nauck M, Dressel A.   +21 more
europepmc   +1 more source

Implementierung des freien Leichtkette-Kappa-Index in die klinische Routine

Hintergrund: Der freie Leichtketten-Kappa-Index (k-FLC-Index) wird zunehmend für sein diagnostisches Potenzial bei Multipler Sklerose (MS) und Klinisch Isoliertem Syndrom (KIS) anerkannt. Ziel dieser Studie war es, die diagnostische Wertigkeit des k-FLC-Index im Vergleich zu Oligoklonalen Banden (OKB), dem aktuellen Goldstandard für den Nachweis der ...
openaire   +1 more source

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Optimization of Bleaching Process and Evaluation of Pulp Performance for Super-Arundo Donax Kraft Pulp. [PDF]

Polymers (Basel)
Cai Z, Ji X, Liang J, Tian Z, Zhou J.
europepmc   +1 more source

Effect of Alkyl Chain Length on the Bandgap, Ferroelectric, and Photoelectric Properties of Lead‐Based Molecular Ferroelectrics

Advanced Science, EarlyView.
This study develops a novel 2D molecular ferroelectric [C6N2H18]PbI4 with polarization enhanced photovoltaics. It systematically investigates the effect of alkylamine spacer cation chain lengths on the band gap, ferroelectric, and photoelectric properties, offering new design strategies.
Ganghua Zhang, Jinrong Wen, Ping Chen, Zhibo Chen, Pingying Tang, Dezeng Li, Jingshan Hou, Yongzheng Fang   +7 more
wiley   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

Advanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong, James Trevarthen, Igor Dolbnya, Wadwan Singhapong, Nicholas Pilato, Richard Butler, Jiraphant Srisuriyachot, Alexander J. G. Lunt   +7 more
wiley   +1 more source

Kappa Free Light Chains Reflect Treatment Response and Progression Independent of Focal Inflammation in Multiple Sclerosis. [PDF]

Eur J Neurol
Rosenstein I, Axelsson M, Johnsson M, Malmeström C, Kvartsberg H, Zetterberg H, Lycke J, Novakova L.   +7 more
europepmc   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Biological Maturation Is Associated with Single-Leg Jump Performance, but Not with the Magnitude of Inter-Limb Asymmetry. [PDF]

Sports (Basel)
Boccia G, Paurini G, Villano D, Marocco R, Ungureanu AN, Beratto L, Brustio PR, Rainoldi A, Lupo C.   +8 more
europepmc   +1 more source