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Kappa-index: Real-life evaluation of a new tool for multiple sclerosis diagnosis
Clinical Immunology, 2022The intrathecal production of oligoclonal immunoglobulin bands (OCB) is a prognostic factor for multiple sclerosis (MS) evolution in clinically isolated syndrome (CIS) patients and a diagnostic factor for MS. The kappa free light chain (K)-index represents a quantitative automated alternative to OCB. We retrospectively evaluated OCB and K-index results
Damien Biotti +2 more
exaly +3 more sources
Kappa free light chain index as a diagnostic biomarker in multiple sclerosis: A real‐world investigation [PDF]
Journal of Neurochemistry, 2021 AbstractKappa free light chain (KFLC) index, a measure for intrathecal production of free kappa chains, has been increasingly recognized for its diagnostic potential in multiple sclerosis (MS) as a quantitative alternative to IgG oligoclonal bands (OCBs).
Igal Rosenstein +2 more
exaly +4 more sources
Validation and meta-analysis of kappa index biomarker in multiple sclerosis diagnosis
Autoimmunity Reviews, 2019The importance of studying the cerebrospinal fluid (CSF) in Multiple Sclerosis (MS) is included in the last McDonald criteria (2018). The study of oligoclonal IgG bands (OCGB) assay is strongly recommended in some situations in which MS diagnosis is uncertain. New biomarkers are developed during the last years. Kappa free light chains (FLC) can predict
M Isabel Garcia-Sanchez +2 more
exaly +3 more sources
Clinical Chemistry and Laboratory Medicine, 2018 Abstract Background Detection of intrathecal immunoglobulin G (IgG) synthesis by gold standard oligoclonal bands (OCB) or IgG index remains an integral part of multiple sclerosis (MS) diagnostics, although both methods have weaknesses.
Mikkel Carstensen +2 more
exaly +4 more sources
An Index of Molecular Flexibility from Kappa Shape Attributes
QSAR and Combinatorial Science, 1989AbstractAn index encoding the structural attribute known as flexibility has been devised based upon the chemical graph. The flexibility definition is based upon the role of molecular size, branching, cycles and heteroatom content. The calculation of the index, phi, uses information from the kappa indexes to encode these contributions.
Lemont B Kier
exaly +2 more sources
Introducing the vectorial Kappa: An index to quantify congruence between vectorial mosaics [PDF]
Ecological Indicators, 2015 This paper introduces the vectorial Kappa (κv) that one can utilize to assess congruence between two vectorial mosaics. The vectorial Kappa extends for vectorial mosaics the approach of the so-called Cohen's Kappa index, commonly used to compare raster mosaics.
Vincent Bonhomme, Cedric Gaucherel
exaly +3 more sources
Index of light kappa/lambda and lambda/kappa chains in monoclonal gammopathies.
Neoplasma, 1990Concentrations of the light chains kappa and lambda were determined by simple radial immunodiffusion in the blood sera of 437 patients with monoclonal gammopathies. The kappa/lambda index was calculated in monoclonal gammopathies with the antigenic type of kappa light chains, while in monoclonal gammopathies with the antigenic type of lambda light ...
M, Tichý, Z, Hrncír
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Kappa index in the diagnostic work-up of autoimmune encephalitis
Journal of the Neurological SciencesThe presence of inflammatory changes in the cerebrospinal fluid (CSF), including immunoglobulin intrathecal synthesis (IS), can support the diagnosis of autoimmune encephalitis (AE) and allow prompt treatment. The main aim of our study was to calculate the Kappa index as a marker of IS, in patients with AE.Charts of patients undergoing a diagnostic ...
Roberta Bedin +2 more
exaly +3 more sources
A Ratio Estimator of the Kappa Index of Agreement Between Two Observers
Biometrical Journal, 1987AbstractThe kappa index is usually used for measuring the agreement between two observers when the scale is nominal. A modification of Cohen's kappa index was given by Krauth. The new estimator was biased and its large sample variance was obtained. An alternative estimator is developed here It is a ratio estimator and its mean square error is derived ...
C N Bouza
exaly +2 more sources
Journal of Chemical Information and Computer Sciences, 2004
The structural interpretation is extended to the topological indices describing cyclic structures. Three representatives of the topological index, such as the molecular connectivity index, the Kappa index, and the atom-type E-State index, are interpreted by mining out, through projection pursuit combining with a number theory method generating ...
Qian-Nan Hu +4 more
openaire +2 more sources
The structural interpretation is extended to the topological indices describing cyclic structures. Three representatives of the topological index, such as the molecular connectivity index, the Kappa index, and the atom-type E-State index, are interpreted by mining out, through projection pursuit combining with a number theory method generating ...
Qian-Nan Hu +4 more
openaire +2 more sources