Results 181 to 190 of about 89,619 (298)

A new hematologic syndrome with a distinct karyotype: the 5 q-- chromosome

open access: bronze, 1975
G. Sokal   +8 more
openalex   +1 more source

Epigenetic Clock Analysis of Sex Chromosome Aneuploidies

open access: yesAging Cell, EarlyView.
Next‐generation epigenetic clocks indicate lower age acceleration and slower pace of aging in 47,XXY than 46,XX, 46,XY, and 47,XYY. A first‐generation clock (Skin & Blood) indicates higher age acceleration in 47,XXY and 47,XYY than 46,XY, while higher naïve CD8+ T in 47,XXY than both 46,XY and 46,XX suggests reduced immunosenescence.
Joshua Zhang   +7 more
wiley   +1 more source

Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Cognitive Decline by Restoring Senescent Microglial Function via NF‐κB‐SREBP1 Pathway Inhibition

open access: yesAging Cell, EarlyView.
Human umbilical cord‐derived mesenchymal stem cells (hUC‐MSCs) ameliorate age‐related cognitive decline by targeting senescent microglia. They attenuate microglial senescence, reduce LD accumulation, and inhibit the NF‐κB‐SREBP1 signaling pathway, ultimately mitigating neuroinflammation and neuronal damage.
Aihong Liang   +13 more
wiley   +1 more source

The PreGen Research Program: Implementing Prenatal Genomic Testing in Australia—A Commentary

open access: yesAustralian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Prenatal genomic sequencing, which can provide a significantly increased diagnostic rate for fetal structural anomaly (FSA) compared with karyotype and microarray, is not available uniformly across Australia. PreGen, a 5‐year translational research program, has identified significant barriers to implementation including access to funding, the ...
Sarah Long   +17 more
wiley   +1 more source

The Effect of Assisted Reproductive Technologies on Human Sex Ratios

open access: yesAustralian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Background Modern assisted reproductive technology (ART), including pre‐implantation genetic testing for aneuploidy (PGT‐A), has opened new avenues in understanding early embryonic events and has simultaneously raised questions about the impact of ART itself on sex ratios.
Ektoras X. Georgiou   +6 more
wiley   +1 more source

Plain Language Summary of the ACCEPT Guideline for the Management of Recurrent Pregnancy Loss

open access: yesAustralian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Recurrent pregnancy loss (RPL) is when a woman experiences two or more pregnancy losses. Investigating for causes of RPL can provide an explanation and possible treatment options. This is a summary of Parts 1 and 2 of Australasian Recurrent Pregnancy Loss Clinical Management Guidelines in an easy‐to‐read patient friendly format. These original
Adriana Suker   +4 more
wiley   +1 more source

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