Results 11 to 20 of about 62,760 (341)

Digital karyotyping [PDF]

Proceedings of the National Academy of Sciences, 2002
Alterations in the genetic content of a cell are the underlying cause of many human diseases, including cancers. We have developed a method, called digital karyotyping, that provides quantitative analysis of DNA copy number at high resolution. This approach involves the isolation and enumeration of short sequence tags from specific genomic loci ...
Christoph Lengauer, Tian Li Wang, Michael R. Speicher, Christine Maierhofer, Victor E. Velculescu, Bert Vogelstein, Kenneth W. Kinzler   +6 more
openaire   +3 more sources

Karyotype evolution in Fusarium [PDF]

IMA Fungus, 2018
The germ tube burst method (GTBM) was employed to examine karyotypes of 33 Fusarium species representative of 11 species complexes that span the phylogenetic breadth of the genus. The karyotypes revealed that the nucleolar organizing region (NOR), which includes the ribosomal rDNA region, was telomeric in the species where it was discernible.
Waalwijk, C., Taga, M., Zheng, S.L., Proctor, R.H., Vaughan, M.M., O'Donnell, K.   +5 more
openaire   +4 more sources

Seven-fluorochrome mouse M-FISH for high-resolution analysis of interchromosomal rearrangements [PDF]

, 2003
The mouse has evolved to be the primary mammalian genetic model organism. Important applications include the modeling of human cancer and cloning experiments. In both settings, a detailed analysis of the mouse genome is essential.
Geigl, J., Jentsch, I., Klein, C. A., Speicher, M. R.   +3 more
core   +1 more source

The use of an e-learning constructivist solution in workplace learning [PDF]

, 2009
We wished to investigate whether an e-learning approach which uses constructivist principles can be successfully applied to train employees in a highly specialised skill thought to require expert individuals and extensive prolonged training. The approach
A. Mileham, A.M. Payne, Anderson, Atkinson, Brown, Brown, Carroll, Carroll, D.K. Griffin, de Jong, Dewhurst, Ducos, Ducos, Ducos, Ducos, Duffy, Farmer, Gibbons, Gibbons, Green, H.G. Tempest, Heerman, Holt, Hughes, Ivancic, J.E. Stephenson, Jonassen, Knowles, Knowles, Kofman, Leathard, Maury, Miller, Modell, Pinton, Popescu, Quilter, Rieber, Smith, van Merrienboer, W.B. Morris, Wang, Wolstenholme   +42 more
core   +1 more source

Evolution of Karyotypes in Chameleons [PDF]

Genes, 2017
The reconstruction of the evolutionary dynamics of karyotypes and sex determining systems in squamate reptiles is precluded by the lack of data in many groups including most chameleons (Squamata: Acrodonta: Chamaeleonidae). We performed cytogenetic analysis in 16 species of chameleons from 8 genera covering the phylogenetic diversity of the family and ...
Martina Johnson Pokorná, Martina Johnson Pokorná, Petr Velenský, Lukáš Kratochvíl, Marie Altmanová, Antonio Sánchez Baca, Michail Rovatsos   +6 more
openaire   +2 more sources

Application of chromosome microarray analysis and karyotyping in diagnostic assessment of abnormal Down syndrome screening results

BMC Pregnancy and Childbirth, 2022
Background Down syndrome (DS) is the most common congenital cause of intellectual disability and also leads to numerous metabolic and structural problems.
Han Kang, Lingxi Wang, Xingyu Li, Chonglan Gao, Yamei Xie, Yu Hu   +5 more
doaj   +1 more source

High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells. [PDF]

, 2017
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) offers the possibility of studying the molecular mechanisms underlying human diseases in cell types difficult to extract from living patients, such as neurons and cardiomyocytes.
Arias, Angelo, D'Antonio, Matteo, D'Antonio-Chronowska, Agnieszka, Frazer, Kelly A, Goldstein, Lawrence SB, Herrera, Cheryl, Matsui, Hiroko, Nathanson, Jason L, Panopoulos, Athanasia D, Reyna, Sol M, Williams, Roy, Woodruff, Grace, Yeo, Gene W   +12 more
core   +2 more sources

High-Throughput Genotyping of Common Chromosomal Inversions in the Afrotropical Malaria Mosquito Anopheles Funestus

Insects, 2020
Polymorphic chromosomal inversions have been implicated in local adaptation. In anopheline mosquitoes, inversions also contribute to epidemiologically relevant phenotypes such as resting behavior.
Martin Lukindu, R. Rebecca Love, Moussa W. Guelbeogo, Scott T. Small, Melissa T. Stephens, Nathan R. Campbell, N’Fale Sagnon, Carlo Costantini, Nora J. Besansky   +8 more
doaj   +1 more source

Multicolour interphase cytogenetics: 24 chromosome probes, 6 colours, 4 layers [PDF]

, 2011
From the late 1980s onwards, the use of DNA probes to visualise sequences on individual chromosomes (fluorescent in-situ hybridisation - FISH) revolutionised the study of cytogenetics.
A.R. Thornhill, Abruzzo, Arnold, Camps, Celeda, Cremer, D. Ioannou, D.K. Griffin, Dauwerse, DeSilva, E.J. Meershoek, Egozcue, Emmerich, Ersfeld, Fiegler, Finch, Finch, Foster, Gabriel, Griffin, Griffin, Griffin, Griffin, Griffin, Handyside, Harper, Harper, Harton, Jauch, Julien, Kallioniemi, Kearns, Kolluri, Langer, Lichter, M. Ellis, Mann, Matsuzaki, Muller, Munne, Munne, Munne, Munne, Nederlof, Nordgren, Olszewska, O’Keefe, Pinkel, Quilter, Rennstam, Roberts, Rodriguez, Rottger, Sbracia, Schardin, Schrock, Speicher, Syvanen, Tempest, Tsuchiya, Walling, Wienberg   +61 more
core   +1 more source

Prevalence of chromosome anomalies in a deer farm with fertility decline in Malaysia

Future Science OA, 2020
Background: A number of factors are known to reduce fertility rate in animals and one of the important categories of such factors is chromosome anomalies. They can occur with or without causing phenotypic abnormalities on animals; in some cases, they may
Muhammad Sanusi Yahaya, Mohd Shahrom Salisi, Nur Mahiza Md Isa, Goh Yong Meng, Abdwahid Haron   +4 more
doaj   +1 more source