Results 271 to 280 of about 140,678 (408)

Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells

open access: yesCell Proliferation, EarlyView.
hESCsdel18q exhibit delayed and impaired anterior neuroectoderm induction, leading to deficient RPE specification. hESCsdel18q lines showed dysregulation of TGFβ signalling, and endogenous overactivation of activin/nodal/TGFβ in hESCsdel18q leads to improper anterior/posterior neuroectodermal fate commitments.
Yingnan Lei   +9 more
wiley   +1 more source

Challenging Conventional Diagnostic Methods by Comprehensive Molecular Diagnostics: A Nationwide Prospective Comparison in Children With ALL. [PDF]

open access: yesJCO Precis Oncol
Boer JM   +12 more
europepmc   +1 more source

Large‐Scale Production of Expandable Hepatoblast Organoids and Polarised Hepatocyte Organoids From hESCs Under 3D Static and Dynamic Suspension Conditions

open access: yesCell Proliferation, EarlyView.
Under 3D suspension culture condition, the expandable hepatoblast organoids and mature polarised hepatocyte organoids were established by low concentration of Matrigel from human embryonic stem cells, which recapitulated the gene expression signatures and functions of primary human hepatoblast and hepatocytes.
Haibin Wu   +14 more
wiley   +1 more source

Mitochondrial Mutation Leads to Cardiomyocyte Hypertrophy by Disruption of Mitochondria‐Associated ER Membrane

open access: yesCell Proliferation, EarlyView.
Cardiomyocytes with high m.3243A>G burden exhibited hypertrophic phenotype. Mitochondria dysfunction occurred and tended to become round in cardiomyocytes with high m.3243A>G burden. Mitochondria‐associated ER membrane (MAM) was disrupted in cardiomyocytes with high m.3243A>G burden.
Miao Yu   +10 more
wiley   +1 more source

Advances in the Study of Pluripotent Stem Cells in Livestock

open access: yesCell Proliferation, EarlyView.
Livestock pluripotent stem cells include embryonic stem cells (ESCs) isolated from the inner cell mass of blastocysts and induced pluripotent stem cells (iPSCs) derived from somatic cell reprogramming. They hold significant potential for applications in livestock breed improvement, rapid propagation, human disease modelling and human organ ...
Xinyi Zhou   +6 more
wiley   +1 more source

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