Results 41 to 50 of about 900 (120)

A Clearer Picture: Using Fetal MRI to Diagnose Neck Masses and Predict Airway Compromise

Prenatal Diagnosis, Volume 46, Issue 3, Page 339-347, March 2026.
ABSTRACT Introduction Fetal neck masses are rare but can be life‐threatening if causing airway compromise. Early and accurate diagnosis of these masses allows life‐saving interventions to be undertaken at birth in the form of the EXIT procedure. Methods A single institution case series of all patients referred for fetal MRI to a tertiary center in the ...
Louise Wilson, Elspeth H. Whitby, Ashok Raghavan   +2 more
wiley   +1 more source

Surgical intervention for Kasaback-Merritt Syndrome: A case report

Journal of Pediatric Surgery Case Reports, 2015
Kasabach-Merritt Syndrome (KMS) is an uncommon phenomenon characterized by the presence of a vascular tumor in association with thrombocytopenia, consumption coagulopathy and hemodynamic instability. Typically presents in infancy and involve the skin and
Morris Sasson, J. Alford Flippin, Gary Birken, Fuad Alkhoury   +3 more
doaj   +1 more source

Multifocal Kaposiform Hemangioendothelioma Successfully Treated With Sirolimus Monotherapy

Pediatric Dermatology, Volume 43, Issue 1, Page 158-162, January/February 2026.
ABSTRACT Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor that typically presents in infancy and may be associated with the Kasabach–Merritt phenomenon (KMP). We present a challenging case of multifocal KHE on the leg of an infant, initially suspected at birth to be a reticulate port wine birthmark.
Matthew J. Mahoney, Erin P. Fritz, Alex C. Hoover, Emily G. Greengard, Michael A. Murati, Bradley J. Segura, Daniel D. Miller, John R. Leister, Sheilagh M. Maguiness   +8 more
wiley   +1 more source

Successful Management of Neonatal and Infantile Kaposiform Hemangioendothelioma with Low-Dose Sirolimus Therapy

Journal of Pediatrics: Clinical Practice
Sirolimus is reportedly effective for kaposiform hemangioendothelioma. However, data on the efficacy of low-dose sirolimus therapy remain limited. This report presents two cases of neonatal and infantile kaposiform hemangioendothelioma associated with ...
Yoshimasa Uematsu, MD, Ken-ichiro Konishi, MD, PhD, Kiyoshi Tanaka, MD, PhD, Hajime Takayasu, MD, PhD, Eiichiro Watanabe, MD, PhD, Takuji Tomari, MD, Hitoshi Isohata, MD, Hidehiko Nakanishi, MD. PhD, Daigo Ochiai, MD, PhD, Yusuke Kumamoto, MD, PhD   +9 more
doaj   +1 more source

An Examination of Sirolimus's Role in Endothelial Cells of Kaposiform Haemangioendothelioma

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Kaposiform haemangioendothelioma (KHE) research faces challenges due to the lack of established cell lines and suitable animal models. Our study aimed to establish KHE cell lines, spheroids and refine murine models to mimic disease characteristics, advancing our understanding of KHE pathogenesis and exploring novel therapies. Primary KHE cells
Yanan Li, Chuan Wang, Meng Kong, Li Li, Yi Ji   +4 more
wiley   +1 more source

Congenital hemangiomas with transient neonatal thrombocytopenia: case reports and review of the literature

Frontiers in Pediatrics
Congenital hemangioma with thrombocytopenia is rare and is often mistaken for Kasabach-Merritt phenomenon seen in kaposiform hemangioendothelioma.
Yuan-yang Zheng, Jiajie Lv, Xiaoxi Lin, Chen Hua   +3 more
doaj   +1 more source

Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai, Tianyue Ming, Xiaoli Li, Shu Wang, Zhanying Bi, Jinyi Zuo, Zizhang Cheng, Weijin Sun, Mingguo Xie, Fengzhi Li, Xiongfei Wang, Xueling Qi, Guoming Luan, Woo‐ping Ge, Yuguang Guan   +14 more
wiley   +1 more source

Advancing Precision Medicine: The Role of Genetic Testing and Sequencing Technologies in Identifying Biological Markers for Rare Cancers

Cancer Medicine, Volume 14, Issue 8, April 2025.
ABSTRACT Background Genetic testing and sequencing technologies offer a comprehensive understanding of cancer genetics, providing rapid and cost‐effective solutions. In particular, these advanced technologies play an important role in assessing the complexities of the rare cancer types affecting several systems including the bone, endocrine, digestive,
Joviana Farhat, Lara Alzyoud, Mohammad AlWahsh, Animesh Acharjee, Basem Al‐Omari   +4 more
wiley   +1 more source

Sirolimus treatment for intractable vascular anomalies (SIVA): An open‐label, single‐arm, multicenter, prospective trial

Pediatrics International, Volume 67, Issue 1, January/December 2025.
Abstract Background Intractable vascular anomalies (VAs), including vascular tumors and venous, lymphatic, and mixed malformations, often have severe symptoms and a poor prognosis, highlighting the need for new treatments. We conducted a prospective trial of sirolimus (tablet and granule forms) for the treatment of VAs.
Michio Ozeki, Saori Endo, Shiho Yasue, Ryuta Asada, Akiko M. Saito, Hiroya Hashimoto, Shigeru Ueno, Shoji Watanabe, Motoi Kato, Kyoichi Deie, Shunsuke Nosaka, Mikiko Miyasaka, Akihiro Umezawa, Kentaro Matsuoka, Mototoshi Kato, Tatsuo Kuroda, Takanobu Maekawa, Satoshi Hirakawa, Taizo Furukawa, Shigehisa Fumino, Tatsuro Tajiri, Junkichi Takemoto, Naonori Kawakubo, Akihiro Fujino   +23 more
wiley   +1 more source

Kaposiform Hemangioendothelioma of the Mediastinum With Kasabach-Merritt Phenomenon Presenting With Pericardial Effusion in a 2-Month-Old

Journal of Vascular Anomalies
Kaposiform hemangioendothelioma (KHE) is a rare vascular and lymphatic tumor of childhood that commonly presents on the skin and extremities. KHE of the mediastinum affecting the heart and great vessels is extremely rare and often locally aggressive.
Olivia A. Keane, Carolyn Taylor, Shayla Bergmann   +2 more
doaj   +1 more source