Results 41 to 50 of about 1,067 (157)

Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai, Tianyue Ming, Xiaoli Li, Shu Wang, Zhanying Bi, Jinyi Zuo, Zizhang Cheng, Weijin Sun, Mingguo Xie, Fengzhi Li, Xiongfei Wang, Xueling Qi, Guoming Luan, Woo‐ping Ge, Yuguang Guan   +14 more
wiley   +1 more source

Successful management of Kaposiform Hemangioendothelioma with long-term sirolimus treatment: a case report and review of the literature

Mediterranean Journal of Hematology and Infectious Diseases, 2018
Background: Kaposiform Hemangioendothelioma (KHE) is a rare vascular tumour of the infancy and of the first decade of life. It is locally aggressive and potentially life threatening when associated to consumptive coagulopathy, known as Kasabach-Merritt ...
Matteo Chinello, Daniela Di Carlo, Francesca Olivieri, Rita Balter, Massimiliano De Bortoli, Virginia Vitale, Ada Zaccaron, Elisa Bonetti, Alice Parisi, Simone Cesaro   +9 more
doaj   +1 more source

Advancing Precision Medicine: The Role of Genetic Testing and Sequencing Technologies in Identifying Biological Markers for Rare Cancers

Cancer Medicine, Volume 14, Issue 8, April 2025.
ABSTRACT Background Genetic testing and sequencing technologies offer a comprehensive understanding of cancer genetics, providing rapid and cost‐effective solutions. In particular, these advanced technologies play an important role in assessing the complexities of the rare cancer types affecting several systems including the bone, endocrine, digestive,
Joviana Farhat, Lara Alzyoud, Mohammad AlWahsh, Animesh Acharjee, Basem Al‐Omari   +4 more
wiley   +1 more source

Surgical intervention for Kasaback-Merritt Syndrome: A case report

Journal of Pediatric Surgery Case Reports, 2015
Kasabach-Merritt Syndrome (KMS) is an uncommon phenomenon characterized by the presence of a vascular tumor in association with thrombocytopenia, consumption coagulopathy and hemodynamic instability. Typically presents in infancy and involve the skin and
Morris Sasson, J. Alford Flippin, Gary Birken, Fuad Alkhoury   +3 more
doaj   +1 more source

Ultrasound‐Guided Percutaneous Sclerotherapy With Bleomycin for Management of Infantile Subcutaneous Hemangioma: A Case Report

Clinical Case Reports, Volume 13, Issue 2, February 2025.
ABSTRACT Percutaneous sclerotherapy with bleomycin is an effective, minimally invasive treatment for aggressive pediatric hemangiomas, especially when traditional therapies fail. This approach can improve clinical outcomes, including thrombocytopenia resolution and tumor size reduction, with minimal systemic side effects.
Iman Kiani, Mitra Khalili, Fahimeh Abdollahimajd, Peyman Eshghi, Arash Khameneh Bagheri   +4 more
wiley   +1 more source

Kasabach Merritt Syndrome In A Case Of Angiokeratoma Of Fordyce

Indian Journal of Dermatology, 1999
Haemangioma with thrombocytopaenia, known as kasabach merritt syndrome, is usually reported in association with large haemangiomas. However, it may be associated with multiple small angiomatous naevil.
Rai Reena, Shekar Shiva, Kumar Vimal, Surendran P, Mustafa Mohammed, Srinivas C.R   +5 more
doaj  

Sirolimus treatment for intractable vascular anomalies (SIVA): An open‐label, single‐arm, multicenter, prospective trial

Pediatrics International, Volume 67, Issue 1, January/December 2025.
Abstract Background Intractable vascular anomalies (VAs), including vascular tumors and venous, lymphatic, and mixed malformations, often have severe symptoms and a poor prognosis, highlighting the need for new treatments. We conducted a prospective trial of sirolimus (tablet and granule forms) for the treatment of VAs.
Michio Ozeki, Saori Endo, Shiho Yasue, Ryuta Asada, Akiko M. Saito, Hiroya Hashimoto, Shigeru Ueno, Shoji Watanabe, Motoi Kato, Kyoichi Deie, Shunsuke Nosaka, Mikiko Miyasaka, Akihiro Umezawa, Kentaro Matsuoka, Mototoshi Kato, Tatsuo Kuroda, Takanobu Maekawa, Satoshi Hirakawa, Taizo Furukawa, Shigehisa Fumino, Tatsuro Tajiri, Junkichi Takemoto, Naonori Kawakubo, Akihiro Fujino   +23 more
wiley   +1 more source

Angiosarcoma of the scalp in the elderly: a case series

Journal of the Egyptian Women’s Dermatologic Society
Cutaneous angiosarcoma (AS) is a rare soft tissue malignancy that often mimics various dermatoses, leading to a delay in diagnosis. The rapid rate of progression portends a poor prognosis.
Carol Lobo, Prathibha J.P, Shubha Bhagavan, Vivek M. Pai   +3 more
doaj   +1 more source

Bleomycin electrosclerotherapy for kaposiform hemangioendothelioma with Kasabach–Merritt phenomenon in an adult

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Jakob Veeser, Raphael Wilhelm, Janina Dietzel, Yalda Ghoreishi, Nora Laubach, Nora Elspaß, Maike Kaufhold, Beate Weidenthaler‐Barth, Christian Rose, Stephan Grabbe, Henner Stege, Hadrian Nassabi   +11 more
wiley   +1 more source

Ovarian hemangioma: A rare encounter

Clinical Case Reports, Volume 12, Issue 9, September 2024.
Key Clinical Message Ovarian hemangioma, though rare and asymptomatic, can mimic malignant ovarian tumors, thus it is necessary for comprehensive histopathological and immunohistochemical evaluation for accurate diagnosis and appropriate management.
M. Singh, P. Subedi, B. Adhikari, A. Sherchan, A. Bajrachrya, S. Mohanty, H. P. Dhakal   +6 more
wiley   +1 more source