Results 21 to 30 of about 45 (36)

Interaction and Regulation of Dynein by Meiosis-specific Protein KASH5 in Chromosome Motility

2023
Meiosis generates haploid gametes essential for sexual reproduction. A hallmark of meiosis is homologous pairing of chromosomes during meiotic prophase I which is essential to ensure correct segregation of chromosomes and promote genetic diversity. Errors in this process result in various germline defects, miscarriages, and infertility.
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KIF5B drives meiotic chromosome dynamics via interaction with the KASH5-LINC complex

Summary Telomere-led rapid prophase chromosome movements (RPMs) during meiotic prophase are critical for homologous chromosome pairing and proper meiotic progression. These movements are generated by the cytoskeleton and are transmitted to the telomeres via the LINC complex, yet the cytoplasmic components that generate these forces ...
Y. Ditamo, W. Shi, L. Previato, J. P. Gillies, A. Carbajal, K. P. Nowak, M. L. Marin, M. Kinter, M. E. DeSantis, C. G. Bisig, R. J. Pezza   +10 more
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Kinesin drive meiotic chromosome dynamics via interaction with the KASH5-LINC complex.

bioRxiv : the preprint server for biology
Rapid chromosome movements during meiotic prophase are critical for homologous chromosome pairing and proper meiotic progression. These movements are generated by the cytoskeleton and are transmitted to the telomeres via the LINC complex, yet the cytoplasmic components that generate these forces remain poorly defined.
Y, Ditamo, S, Wanjing, L, Previato, J P, Gillies, A, Carbajal, M, Kinter, M E, DeSantis, C G, Bisig, R J, Pezza   +8 more
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Faculty Opinions recommendation of The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2022
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Homozygous Variant in KASH5 Causes Premature Ovarian Insufficiency by Disordered Meiotic Homologous Pairing

Journal of Clinical Endocrinology and Metabolism, 2022
, Ling Zhang, Ling Zhang
exaly  

Novel bi-allelic variants in KASH5 are associated with meiotic arrest and non-obstructive azoospermia

Molecular Human Reproduction, 2022
, Ruhui Tian, Ling Zhang
exaly  

The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

Journal of Cell Biology, 2023
Philip Woodman, Elizabeth Granger, Owen Davies   +2 more
exaly  

Landscape of pathogenic mutations in premature ovarian insufficiency

Nature Medicine, 2023
, Zi-Jiang Chen, Li Jin
exaly  

The SUN1-SPDYA interaction plays an essential role in meiosis prophase I

Nature Communications, 2021
Qian Bian, Yong Fan, Ming Lei
exaly  

Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes

Journal of Molecular Biology, 2020
Thomas U Schwartz, Fatma Esra Demircioglu, VÍCTOR E Cruz   +2 more
exaly