Results 61 to 66 of about 226 (66)

Conserved genes regulating human sex differentiation, gametogenesis and fertilization. [PDF]

J Transl Med
Fakhro KA, Awwad J, Garibova S, Saraiva LR, Avella M.   +4 more
europepmc   +1 more source

A Dominant Founder Lineage Has Possible Fitness Costs for the Endangered Mexican Grey Wolf. [PDF]

Mol Ecol
Loera Y, Khakoo M, Krueckeberg E, Nilsson IG, Wu Z, Dwire M, Adams J, Waits L, Oakleaf JK, Campbell ML, Dunnum JL, Cook JA, vonHoldt BM.   +12 more
europepmc   +1 more source

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Homozygous Variant in KASH5 Causes Premature Ovarian Insufficiency by Disordered Meiotic Homologous Pairing

The Journal of Clinical Endocrinology & Metabolism, 2022
Abstract Context Premature ovarian insufficiency (POI) affects 1% to 3.7% of women at reproductive age, and its etiology is heterogeneous. The linker of nucleoskeleton and cytoskeleton (LINC) complex, consisting of KASH5 and SUN1, plays an indispensable role in meiotic homolog pairing, determining the
Qian Zhang, Chengqiu Tao, Shuchang Gao, Shan Li, Bingying Xu, Hanni Ke, Yiyang Wang, Feng Zhang, Yingying Qin, Ling Zhang, Ting Guo   +10 more
openaire   +2 more sources

Interaction and Regulation of Dynein by Meiosis-specific Protein KASH5 in Chromosome Motility

2023
Meiosis generates haploid gametes essential for sexual reproduction. A hallmark of meiosis is homologous pairing of chromosomes during meiotic prophase I which is essential to ensure correct segregation of chromosomes and promote genetic diversity. Errors in this process result in various germline defects, miscarriages, and infertility.
openaire   +1 more source

Kinesin drive meiotic chromosome dynamics via interaction with the KASH5-LINC complex

SummaryRapid chromosome movements during meiotic prophase are critical for homologous chromosome pairing and proper meiotic progression. These movements are generated by the cytoskeleton and are transmitted to the telomeres via the LINC complex, yet the cytoplasmic components that generate these forces remain poorly defined.
Y. Ditamo, S. Wanjing, L. Previato, J. P. Gillies, A. Carbajal, M. Kinter, M. E. DeSantis, C.G. Bisig, R. J. Pezza   +8 more
openaire   +1 more source

Faculty Opinions recommendation of The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2022
openaire   +1 more source