Results 131 to 140 of about 58,318 (161)

Selenium and Kashin-Beck Disease

1996
Kashin-Beck Disease (KBD) which hardly attracts attention in the west has been mainly found in remote and poor areas in China. The characteristics of the disease are short stature and deformed joints due to a focalised destruction of the chondrocytes of the articular cartilage and the growth zone (1). Although some factors have been found to be related
openaire   +1 more source

Oxidant damage in Kashin‐Beck disease and a rat Kashin‐Beck disease model by employing T‐2 toxin treatment under selenium deficient conditions

Journal of Orthopaedic Research, 2012
AbstractKashin‐Beck disease (KBD) is an endemic degenerative osteoarthropathy, but the mechanisms underlying its pathogenesis remains unclear. This study compares antioxidant capacity and lipid peroxidation using a novel model, in which rats were administered a selenium‐deficient diet for 4 weeks prior to their exposure to T‐2 toxin for 4 weeks ...
Chen, Jing-hong, Xue, Senghai, Li, Siyuan, Wang, Zhi-lun, Yang, Haojie, Wang, Wei, Song, Daiqing, Zhou, Xiaorong, Chen, Chen   +8 more
openaire   +3 more sources

The interaction of HT-2 toxin and Akt1 on gene expression regulation in Kashin-Beck disease pathogenesis.

Toxicon
BACKGROUND This study investigates the effects of T-2 toxin metabolite HT-2 alone or combined with Akt1 on chondrocyte gene expression to elucidate their roles in Kashin-Beck disease (KBD) pathogenesis.
Xinhua Liao, Xiaodong Yang, Xi Jia, Qian Zhang, G. Naren, Jiaojiao Zhang, Hui Niu, Haiyan Wei, Cuiyan Wu   +8 more
semanticscholar   +1 more source

Transcriptomic and Metabolomic Mechanism of Ibuprofen, Chondroitin Sulfate, and Vitamins With Minerals Tablets (21) for Kashin–Beck Disease Treatment

Rapid Communications in Mass Spectrometry
Kashin–Beck disease (KBD) is an osteoarthropathy with no specific drug treatment. This study seeks to uncover the molecular mechanisms of ibuprofen, chondroitin sulfate, and vitamins with minerals tablets (21) in treating KBD.
Jinfeng Wen, Xingxing Deng, Zhengjun Yang, Hui Niu, Qian Zhang, Yijun Zhao, G. Naren, Huan Liu, Feng Zhang, Xiaodong Yang, Cuiyan Wu   +10 more
semanticscholar   +1 more source

Iodine, Selenium Deficiency and Kashin–Beck Disease

2009
This chapter deals with diseases where both iodine and selenium deficiency play a role in disease causation and particularly with Kashin-Beck Disease (KBD). KBD is an osteoarthropathy endemic in China and Tibet. The condition appears between the ages of 5 and 15 years, and leads to varying degrees of disability throughout adult life.
openaire   +1 more source

The Role of Selenium-Mediated Notch/Hes1 Signaling Pathway in Kashin–Beck Disease Patients and Cartilage Injury Models

Biological Trace Element Research, 2022
Di Zhang, Dandan Zhang, XiaoLi Yang, Qiang Li, Rongqiang Zhang, Y. Xiong   +5 more
semanticscholar   +1 more source

Targets and Potential Mechanism of Chondroitin Sulfate A-selenium Nanoparticle on Kashin-Beck Disease Chondrocytes

Biological Trace Element Research
Huan Deng, F. Deng, Xinyue Wen, Yude Jiang, A. F. Amhare, Lichun Qiao, Miaoqian Li, Ping Wan, Jun Wang, Jing Han   +9 more
semanticscholar   +1 more source

Exploring the role of gut microbiota in the pathogenesis of Kashin-Beck Disease: A Focus on selenium deficiency and T-2 toxin exposure

Medical Hypotheses
Lian Liu, Lulu Bai, Yifan Wu, Yu Zhang, Chaowei Wang, Shujin Li, Yuequan Yuan, Xi Lv, Hui Wang, Yirong Qin, Xiong Guo, Xi Wang, Y. Ning   +12 more
semanticscholar   +1 more source

The Prevalence of Kashin-Beck Disease in China: a Systematic Review and Meta-analysis

Biological Trace Element Research, 2022
JunKui Xu, Junhu Wang, Hongmou Zhao
semanticscholar   +1 more source

Downregulated Expression and Hypermethylation of SIRT1 in Patients with Kashin-Beck Disease–Mediated Chondrocyte Apoptosis May Potentially Be Ameliorated by Selenium Supplement

Biological Trace Element Research
XiaoLi Yang, Lixin Han, Di Zhang, Cuixiang Xu, Zhankui Jin, Y. Xiong   +5 more
semanticscholar   +1 more source